文献类型：期刊文献

英文题名：Self-photocatalyzed Homolytic Dehalogenative Alkylation/Cyclization of Unactivated Alkenes Based on the Quinazolinone Skeleton via Energy Transfer

作者：Sun, Bin[1];Tang, Xiaoli[2];Shi, Rongcheng[2];Yan, Zhiyang[1];Li, Bingqian[2];Tang, Chen[1];Jin, Can[1,2];Wu, Chunlei L.[3];Shen, Runpu P.[3]

机构：[1]Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310032, Peoples R China;[2]Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310032, Peoples R China;[3]Shaoxing Univ, Zhejiang Engn Res Ctr Fat Soluble Vitamin, Shaoxing 312000, Peoples R China

年份：2021

卷号：10

期号：12

起止页码：3390

外文期刊名：ASIAN JOURNAL OF ORGANIC CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:000711548300001)、、Scopus(收录号：2-s2.0-85118214883)、WOS、CCR-EXPANDED(收录号：WOS:000711548300001)

基金：This work was supported by the National Natural Science Foundation of China (22078299), the Natural Science Foundation of Zhejiang Province (LY21B060005 and LQ20B060007) and the Opening Project of Zhejiang Engineering Research Center of Fat-soluble Vitamin (202101). We are also grateful to the College of Pharmaceutical Sciences, Zhejiang University of Technology and Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals for the financial help.

语种：英文

外文关键词：Alkylation; cyclization; Energy transfer; Malonate; Quinazolinone; Self-photocatalyzsis

外文摘要：A mild, external photocatalyst- and additive-free protocol for photo-induced alkylation/cyclization of unactivated alkenes with halides has been developed. This strategy showed excellent regioselectivity and simple operation to synthesize alkyl-substituted quinazolinones with a broad substrate scope. More importantly, chlorinated alkanes were also compatible with this transformation.