文献类型：期刊文献

英文题名：Distinguishing between COVID-19 and influenza during the early stages by measurement of peripheral blood parameters

作者：Chen, Jiangnan[1,2];Pan, Yong[3];Li, Gangfeng[4];Xu, Wenfang[2];Zhang, Lihong[4];Yuan, Shijin[1];Xia, Yan[1];Lu, Pei[2];Zhang, Jun[1]

机构：[1]Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Clin Lab, Sch Med, 3 Qingchun E Rd, Hangzhou 310016, Peoples R China;[2]Shaoxing Univ, Dept Clin Lab, Affiliated Hosp, Shaoxing, Peoples R China;[3]Wenzhou Cent Hosp, Dept Clin Lab, Wenzhou, Peoples R China;[4]Shaoxing Peoples Hosp, Dept Clin Lab, Shaoxing, Peoples R China

年份：2021

卷号：93

期号：2

起止页码：1029

外文期刊名：JOURNAL OF MEDICAL VIROLOGY

收录：SCI-EXPANDED(收录号：WOS:000558704100001)、、Scopus(收录号：2-s2.0-85089312117)、WOS

基金：the Science Technology Bureau of Shaoxing, Grant/Award Number: 2018C30017

语种：英文

外文关键词：biochemical parameters; blood routine parameters; COVID-19; influenza; SARS-CoV-2

外文摘要：Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 infection. This study aims to examine the changes in peripheral blood parameters during the early stages of COVID-19 and influenza. We analyzed the peripheral blood parameters of 169 COVID-19 patients and 131 influenza patients during the early-onset stage. Results from the patients with COVID-19 were compared with those from healthy controls and influenza patients. In addition, results from patients with common and severe COVID-19 were further compared. There were significant differences between COVID-19 and influenza patients in terms of age, white blood cell count, platelet count, percentage of neutrophils, percentage of lymphocytes, percentage of monocytes, percentage of eosinophils, percentage of basophils, neutrophil, count and monocyte count. Two parameters (monocyte count and percentage of basophils) were combined to clarify the diagnostic efficacy of COVID-19 and influenza and the area under the curve was found to be 0.772. Comparison of peripheral blood parameters from common COVID-19, severe COVID-19, and influenza patients revealed many differences during the early disease stages. The diagnostic formula developed by this study will be of benefit for physicians in the differentiation of COVID-19 and influenza.