文献类型：期刊文献

中文题名：控制释放制剂的组成对异丙甲草胺释放速率的影响

英文题名：Influence of Compositions of Controlled Release Formulations on the Release Rate of Metolachlor

作者：李建法[1];吕金红[1];李益民[1]

机构：[1]绍兴文理学院化学系

年份：2008

卷号：10

期号：3

起止页码：361

中文期刊名：农药学学报

外文期刊名：Chinese Journal of Pesticide Science

收录：CSTPCD、、CSCD2011_2012、CSCD

基金：浙江省自然科学基金资助项目(Y306107);绍兴市科技计划项目(2006A32004)

语种：中文

中文关键词：异丙甲草胺;除草剂;海藻酸盐;膨润土;控制释放

外文关键词：metolachlor; herbicide; alginate; bentonite; controlled release

中文摘要：将海藻酸盐与膨润土复合作为载体制备除草剂异丙甲草胺的控制释放制剂，研究了载药量、载体原料配比、膨润土类型等制剂组成因素对异丙甲草胺释放速率的影响。采用Ritger和Peppas方程分析释放动力学过程，计算50％的异丙甲草胺被释放所需时间（t50），并以此表征释放速率。结果表明，采用海藻酸盐／膨润土复合载体时，t50随载药量和载体原料配比不同介于29．4～68．0h之间，控制释放效果明显优于单纯以有机改性膨润土作载体（t50=5．9h）。将有机改性膨润土与海藻酸盐复合作载体时，t50可达110h。释放动力学方程的n值（0．436～0．496）接近Fickian扩散模型，说明该控制释放制剂中异丙甲草胺的释放过程主要受到扩散控制。

外文摘要：The controlled release formulations （CRFs） of herbicide metolachlor were prepared using alginate /bentonites as composite carriers. The influence of formulation compositions, such as the loading amount of herbicide, the ratio of carrier materials, and the types of bentonites, on the release rate was investigated. Ritger and Peppas equation was used to analyze the release kinetics, and the time taken for 50% of the metolachlor to be released （ t50 ） was calculated to compare with the release rate from various formulations. When the alginate/bentonite composite carriers were used, the t50 values varied between 29.4 h to 68.0 h, depending on the change of loading amount of herbicide and ratio of carrier materials. The composite carriers performed much better than the pure organically modified bentonite （t50 = 5.9 h）. But when the organically modified bentonite was used together with alginate, the t50 increased to 110 h. The n values （0.436 -0. 496） of release kinetics of metolachlor from the CRFs were close to that of Fickian diffusion model, indicated a diffusion-dominated release mechanism.