文献类型：期刊文献

英文题名：Visible-Light-Induced Desaturative β-Alkoxyoxalylation of N-Aryl Cyclic Amines with Difluoromethyl Bromides and H₂O Via a Triple Cleavage Process

作者：Sun, Bin[1];Li, Pei-Xuan[1];Jiang, Yu[1];Yang, Lu-Lu[1];Huang, Pan-Yi[1];Shen, Run-Pu[3];Chen, Mao-Jie[1];Wang, Jia-Yang[2];Jin, Can[1]

机构：[1]Zhejiang Univ Technol, Coll Pharmaceut Sci, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Peoples R China;[2]Huzhou Univ, Sch Life Sci, Huzhou 313002, Zhejiang, Peoples R China;[3]Shaoxing Univ, Zhejiang Engn Res Ctr Fatsoluble Vitamin, Shaoxing 312000, Peoples R China

年份：2023

卷号：25

期号：36

起止页码：6773

外文期刊名：ORGANIC LETTERS

收录：SCI-EXPANDED(收录号：WOS:001061190500001)、、Scopus(收录号：2-s2.0-85171393778)、WOS、CCR-EXPANDED(收录号：WOS:001061190500001)

基金：This work was supported by the National NaturalScience Foundation of China (Grant Nos. 22078299 and 22108250), ZhejiangProvincial Natural Science Foundation of China (LY21B060005), andthe Opening Project of Zhejiang Engineering Research Center of Fat-solubleVitamin (202101, 202201, and 202303). We are also grateful to theCollege of Pharmaceutical Sciences, Zhejiang University of Technology,and Collaborative Innovation Center of Yangtze River Delta RegionGreen Pharmaceuticals for the financial help.

语种：英文

外文摘要：A visible-light-driven desaturative beta-alkoxyoxalyation of N-aryl cyclic amines with difluoromethyl bromides and H2O has been reported. This tandem reaction is triggered by homolysis of the C-Br bond to produce the difuoroalkyl radical, which undergoes the subsequent defluorinated beta-alkoxyoxalylation cascades to afford a wide range of beta-ketoester/ketoamides substituted enamines. The prominent feature of this reaction contains photocatalyst-free, transition-metal free, and mild conditions. The O-18 labeling experiment disclosed that H2O is the oxygen source of the carbonyl unit.