文献类型：期刊文献

英文题名：Elevated Levels of Foreign Microparticles in the Blood of Patients with Digestive System Diseases

作者：Song, Jie[1,3];Wang, Yunqing[2,4];Ji, Yunxia[1,3];Wang, Meirong[1];Yuan, Qi[2];Lv, Changjun[3];Chen, Lingxin[2,4]

机构：[1]Binzhou Med Univ, Sch Pharmaceut Sci, Dept Cellular & Genet Med, Yantai 264003, Peoples R China;[2]Chinese Acad Sci, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China;[3]Binzhou Med Univ, Binzhou Med Univ Hosp, Dept Resp & Crit Care Med, Binzhou 256603, Peoples R China;[4]Shaoxing Univ, Coll Chem & Chem Engn, Shaoxing 312000, Peoples R China

年份：2025

卷号：12

期号：5

起止页码：503

外文期刊名：ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS

收录：SCI-EXPANDED(收录号：WOS:001466581600001)、、EI(收录号：20251618253521)、Scopus(收录号：2-s2.0-105002685332)、WOS

基金：This study is financially supported by the National Natural Science Foundation of China (Nos. 42076199, 42476190, 22376216, 21976209), Taishan Scholar Project Special Funding (No. tsqn202211262, ts20190962) and the Special Fund for Leading Scholar Program of Yantai. Table of content graphic created with BioRender.com.

语种：英文

外文关键词：Digestive system diseases; Blood; Microparticleidentification; Microplastics; Raman detection

外文摘要：Exogenous microparticles can penetrate the bloodstream through the digestive tract, causing systemic toxic effects, but this phenomenon has long been overlooked. Digestive disease patients, as a vulnerable group, have not been adequately studied regarding blood particulate pollution compared to healthy individuals. In this study, blood samples from 26 patients with digestive system diseases and 29 healthy controls were collected, and a method for blood sample digestion and microparticle separation was developed. Employing Raman spectroscopy, laser-induced breakdown spectroscopy, and scanning electron microscopy with energy dispersive X-ray spectroscopy, 7 types of materials were identified from 846 observed microparticles, including calcium carbonate, phthalocyanine, iron sesquioxide, and carbon. Notably, this study for the first time revealed that patients with digestive system diseases had a significantly higher quantity and larger size of exogenous microparticles in their blood. This implies that digestive diseases might enhance the nonselective gut permeability to microparticles and the risk of systemic organ exposure to particulate pollution. These findings offer new insights into the mechanisms of particulate transport within the body and provide valuable evidence for understanding the pathogenesis of complications in digestive diseases (such as thrombosis) and dietary recommendations for patients.