文献类型：期刊文献

英文题名：Palladium-Catalyzed C8 Alkylation of 1-Naphthylamides with Alkyl Halides via Bidentate-Chelation Assistance

作者：Huang, Lehao[2];Sun, Xudong[1];Li, Qian[1];Qi, Chenze[1]

机构：[1]Shaoxing Univ, Inst Appl Chem, Zhejiang Key Lab Alternat Technol Fine Chem Proc, Shaoxing 312000, Zhejiang, Peoples R China;[2]Wenzhou Med Univ, Renji Coll, Wenzhou 325035, Zhejiang, Peoples R China

年份：2014

卷号：79

期号：14

起止页码：6720

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:000339368300034)、、EI(收录号：20143017988820)、Scopus(收录号：2-s2.0-84904563244)、WOS

基金：We are grateful to the National Natural Science Foundation of China (Grant 21172149), the Zhejiang Provincial Natural Science Foundation of China (Grant LQ13B020001), Key Sci-Tech Innovation Team Project of Zhejiang Province (Grants 2012R10014-14 and 2010R50014-18), and the Foundation of Science and Technology Bureau of Shaoxing (2013B70018) for financial support.

语种：英文

外文关键词：Amides - Catalysis - Chlorine compounds - Palladium compounds

外文摘要：A Pd-catalyzed regioselective alkylation of C8-H bonds in 1-naphthylamides containing a quinolinamide or picolinamide moiety as a bidentate directing group with alkyl halides is reported. The amide directing group can be easily hydrolyzed under basic conditions. Various alkyl halides including alkyl iodides and benzyl bromide or chloride can be employed as coupling partners, exclusively providing 8-alkyl-1-naphthylamide derivatives.