文献类型：期刊文献

英文题名：TREM-1 as a potential prognostic biomarker associated with immune infiltration in clear cell renal cell carcinoma

作者：Pu, Yaling[1];Cai, Danyang[2];Jin, Lingling[3];Xu, Fenfen[4];Ye, Enru[3];Wu, Lina[5];Mo, Licai[6];Liu, Suzhi[1,7];Guo, Qunyi[8];Wu, Gang[4]

机构：[1]Shao Xing Univ, Taizhou Hosp Zhejiang Prov, 150 Ximen St, Taizhou 317000, Zhejiang, Peoples R China;[2]Wenzhou Med Univ, Taizhou Hosp Zhejiang Prov, Dept Radiat Oncol, 150 Ximen St, Taizhou 317000, Zhejiang, Peoples R China;[3]Wenzhou Med Univ, Taizhou Hosp Zhejiang Prov, Dept Pathol, 150 Ximen St, Taizhou 317000, Zhejiang, Peoples R China;[4]Wenzhou Med Univ, Taizhou Hosp Zhejiang Prov, Dept Pharm, 150 Ximen St, Taizhou 317000, Zhejiang, Peoples R China;[5]Taizhou Enze Med Ctr, Enze Hosp, Dept Pathol, 150 Ximen St, Taizhou 317000, Zhejiang, Peoples R China;[6]Wenzhou Med Univ, Taizhou Hosp Zhejiang Prov, Dept Urol, 150 Ximen St, Taizhou 317000, Zhejiang, Peoples R China;[7]Wenzhou Med Univ, Taizhou Hosp Zhejiang Prov, Dept Neurol, 150 Ximen St, Taizhou 317000, Zhejiang, Peoples R China;[8]Wenzhou Med Univ, Taizhou Hosp Zhejiang Prov, Dept Hematol & Oncol, 150 Ximen St, Taizhou 317000, Zhejiang, Peoples R China

年份：2023

卷号：21

期号：1

外文期刊名：WORLD JOURNAL OF SURGICAL ONCOLOGY

收录：SCI-EXPANDED(收录号：WOS:000993833800001)、、Scopus(收录号：2-s2.0-85159841805)、WOS

语种：英文

外文关键词：Immune-related signature; Clear cell renal cell carcinoma; The Cancer Genome Atlas; Tumor immune microenvironment; TREM-1

外文摘要：BackgroundThe tumor immune microenvironment plays a crucial role in the efficacy of various therapeutics. However, their correlation is not yet completely understood in Clear cell renal cell carcinoma (ccRCC). This study aimed to investigate the potential of TREM-1 as a potential novel biomarker for ccRCC.MethodsWe constructed a ccRCC immune prognostic signature. The clinical characteristics, the status of the tumor microenvironment, and immune infiltration were analyzed through the ESTIMATE and CIBERSORT algorithms for the hub gene, while the Gene Set Enrichment Analysis and PPI analysis were performed to predict the function of the hub gene. Immunohistochemical staining was used to detect the expression of TREM-1 in renal clear cell carcinoma tissues.ResultsThe CIBERSORT and ESTIMATE algorithms revealed that TREM-1 was correlated with the infiltration of 12 types of immune cells. Therefore, it was determined that TREM-1 was involved in numerous classical pathways in the immune response via GSEA analysis. In Immunohistochemical staining, we found that the expression of TREM-1 was significantly upregulated with increasing tumor grade in renal clear cell carcinoma, and elevated TREM-1 expression was associated with poor prognosis.ConclusionsThe results suggest that TREM-1 may act as an implicit novel prognostic biomarker in ccRCC that could be utilized to facilitate immunotherapeutic strategy.