文献类型：期刊文献

英文题名：Abnormal gray matter structure in children and adolescents with high-functioning autism spectrum disorder

作者：Sun, Fenfen[1,2];Chen, Yue[1,2];Gao, Qiyang[1,2];Zhao, Zhiyong[3]

机构：[1]Shaoxing Univ, Ctr Brain Mind & Educ, Shaoxing 312000, Peoples R China;[2]Shaoxing Univ, Dept Psychol, Shaoxing 312000, Peoples R China;[3]Zhejiang Univ, Coll Biomed Engn & Instrument Sci, Hangzhou 310027, Peoples R China

年份：2022

卷号：327

外文期刊名：PSYCHIATRY RESEARCH-NEUROIMAGING

收录：SCI-EXPANDED(收录号：WOS:000890468900002)、、Scopus(收录号：2-s2.0-85141754544)、WOS

基金：Funding This work was supported by a grant sponsored by the Research Program of Zhejiang Federation of Humanities and Social Sciences Cir-cles [2023N089] .

语种：英文

外文关键词：Autism spectrum disorder; Gray matter volume; density; Regression analysis; Magnetic resonance imaging; Children and adolescents

外文摘要：The present study aimed to explore the brain structural mechanisms underlying clinical dysfunction in patients with ASD using magnetic resonance imaging (MRI). After screening T1 structural images from the Autism Brain Imaging Data Exchange (ABIDE) database, 111 children and adolescents with high-functioning ASD and 151 typically developing (TD) subjects matched were included in this study. We first compared the differences in gray matter volume (GMV) and gray matter density (GMD) between the two groups. Then, the relationships between GMV/GMD and clinical assessments in ASD patients were evaluated. We found that compared with the TD group, the ASD group showed increased GMV/GMD in the precuneus, thalamus, hippocampus and cingulate gyrus. Moreover, in the ASD group, social interaction was negatively correlated with GMD in the bilateral superior temporal gyrus and limbic system; communication was positively correlated with GMD in the right middle temporal gyrus, inferior frontal gyrus, and anterior cingulate gyrus; and repetitive behavior was positively correlated with GMD in the cerebellum and negatively correlated with GMV in the prefrontal cortex. In conclusion, the gray matter structure in children and adolescents with ASD was abnormal, and different clinical dysfunctions in ASD patients were related to structural abnormalities in specific regions.