文献类型：期刊文献

英文题名：Ellagic acid activates the Keap1-Nrf2-ARE signaling pathway in improving Parkinson?s disease: A review

作者：Wang, Qianhui[1];Botchway, Benson O. A.[2];Zhang, Yong[1];Liu, Xuehong[1,3]

机构：[1]Shaoxing Univ, Med Coll, Dept Histol & Embryol, Zhejiang, Peoples R China;[2]Zhejiang Univ, Sch Med, Inst Neurosci, Hangzhou, Peoples R China;[3]Shaoxing Univ, Med Coll, Dept Histol & Embryol, Shaoxing 312000, Zhejiang, Peoples R China

年份：2022

卷号：156

外文期刊名：BIOMEDICINE & PHARMACOTHERAPY

收录：SCI-EXPANDED(收录号：WOS:000874584000008)、、Scopus(收录号：2-s2.0-85139733914)、WOS

语种：英文

外文关键词：Ellagic acid; Parkinson?s disease; Keap1-Nrf2-ARE signaling pathway; Oxidative stress

外文摘要：Parkinson's disease (PD) is a familiar neurodegenerative disease, accompanied by motor retardation, static tremor, memory decline and dementia. Heredity, environment, age and oxidative stress have been suggested as key factors in the instigation of PD. The Keap1-Nrf2-ARE signaling is one of the most significant anti-oxidative stress (OS) pathways. The Keap1 is a negative regulator of the Nrf2. The Keap1-Nrf2-ARE pathway can induce cell oxidation resistance and reduce nerve injury to treat neurodegenerative diseases. Ellagic acid (EA) can inhibit the Keap1 to accumulate the Nrf2 in the nucleus, and act on the ARE to produce target proteins, which in turn may alleviate the impact of OS on neuronal cells of PD. This review analyzes the structure and physiological role of EA, along with the structure, composition and functions of the Keap1-Nrf2-ARE signaling pathway. We further expound on the mechanism of ellagic acid in its activation of the Keap1-Nrf2-ARE signaling pathway, as well as the relationship between EA in impairing the TLR4/Myd88/NF-kappa B and Nrf2 pathways. Ellagic acid has the potentiality of improving PD by activating the Keap1-Nrf2-ARE signaling pathway and scavenging free radicals.