文献类型：期刊文献

英文题名：Metal-N-Heterocyclic Carbene Complexes as Anti-Tumor Agents

作者：Hu, Chunqi[1];Li, Xin[2];Wang, Wei[3];Zhang, Ruoyu[4];Deng, Liping[1,3]

机构：[1]Shaoxing Univ, Dept Pharmacol, Chem & Chem Engn Inst, Shaoxing 312000, Zhejiang, Peoples R China;[2]Zhejiang Univ, Sch Pharmaceut Sci, ZJU ENS Joint Lab Med Chem, Hangzhou 310058, Zhejiang, Peoples R China;[3]Zhejiang Supor Pharmaceut, Shaoxing 312000, Zhejiang, Peoples R China;[4]Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Geriatr, Hangzhou 310009, Zhejiang, Peoples R China

年份：2014

卷号：21

期号：10

起止页码：1220

外文期刊名：CURRENT MEDICINAL CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:000332531900005)、、Scopus(收录号：2-s2.0-84896300051)、WOS

基金：This study was financially supported by Zhejiang Provincial Natural Science Foundation of China under Grant (No. LQ13H300001 and No. Y2100872), and supported by the National Science Foundation for Young Scholars of China under Grant (No. 81202411 and No. 81100241).

语种：英文

外文关键词：NHCs; NHC-metal complexes; anti-tumor; biological evaluation

外文摘要：It has been a long story of the development of anticancer metallopharmaceuticals since the identification of cisplatin. Advances in metallodrugs discovery during the past 40 years have made it an ever-growing area of research in medicinal inorganic chemistry. Meanwhile, the emerging of N-heterocyclic carbene (NHC) chemistry has stimulated the newly burgeoning interests in the biomedical applications of metal-NHC complexes. This review will detail what have been achieved hitherto in the research of metal-NHC complexes as potential anti-tumor agents coupled with gold, silver, copper, platinum and palladium. Their mechanism of action will also be discussed. All the results obtained indicate that this promising approach is worthy of more focuses and further studies.