文献类型：期刊文献

英文题名：Insights into the pharmacological and therapeutic effects of apigenin in liver injuries and diseases

作者：Bi, Chenchen[1,2];Han, Wenwen[2];Yu, Jingru[2];Zhang, Huafang[1];Xing, Guiying[1];Liu, Zheng[1]

机构：[1]Shaoxing Univ, Sch Med, Dept Pharmacol, Shaoxing, Zhejiang, Peoples R China;[2]Shaoxing Univ, Sch Med, Dept Clin Med, Shaoxing, Zhejiang, Peoples R China

年份：2023

卷号：9

期号：5

外文期刊名：HELIYON

收录：SCI-EXPANDED(收录号：WOS:001026397000001)、、Scopus(收录号：2-s2.0-85153503679)、WOS

基金：This work was funded by Yue Di Element General Curriculum Project of Shaoxing Higher Education Institutions (No. 20225306) and the Science and Technology Planning Project of Shaoxing City (No. 2020A13061) . We thank LetPub ( www.letpub.com ) for its linguistic assistance during the preparation of this manuscript.

语种：英文

外文关键词：Apigenin; Liver injuries and diseases; Phytochemistry; Pharmacological effects; Toxicology

外文摘要：Background: Liver diseases are a spectrum of diseases that include hepatic steatosis, nonalcoholic fatty liver disease, hepatitis, liver fibrosis, cirrhosis, and hepatic cancer. These diseases not only severely decrease the quality of life for patients, but also cause financial burden. Although apigenin (APG) has recently become the primary treatment for liver injuries and diseases (LIADs), there has been no systematic review of its use.Purpose: To review the existing literature and put forward novel strategies for future APG research on LIADs.Methods: A search was conducted in PubMed, Science Direct, Research Gate, Web of Science, VIP, Wanfang, and CNKI, and 809 articles were obtained. After applying inclusion and exclusion criteria, 135 articles were included.Results: APG is promising in treating LIADs via various mechanisms arising from its antiinflammation, anti-proliferation, anti-infection, anti-oxidation, and anti-cancer properties.Conclusion: This review summarizes the evidence supporting the use of APG as a treatment for LIADs and provides an insight into the intestinal microbiota, which may have important implications in its future clinical use.