文献类型：期刊文献

英文题名：Palladium-catalyzed native alpha-amino acid derivative-directed arylation/oxidation of benzylic C-H bonds: synthesis of 5-aryl-1,4-benzodiazepin-2-ones

作者：Jiang, Fengxuan[1,2];Xu, Menghua[3];Bei, Wenfeng[1];Cheng, Kai[1];Huang, Lehao[2]

机构：[1]Shaoxing Univ, Inst Appl Chem, Key Lab Alternat Technol Fine Chem Proc, Shaoxing 312000, Zhejiang, Peoples R China;[2]Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China;[3]China Pharmaceut Univ, Dept Med Chem, State Key Lab Nat Med, Jiangsu Key Lab Bioact Nat Prod Res, Nanjing 210009, Peoples R China

年份：2022

卷号：58

期号：69

起止页码：9638

外文期刊名：CHEMICAL COMMUNICATIONS

收录：SCI-EXPANDED(收录号：WOS:000837412900001)、、EI(收录号：20223412616528)、Scopus(收录号：2-s2.0-85136213915)、WOS、CCR-EXPANDED(收录号：WOS:000837412900001)

基金：We are grateful to the Zhejiang Provincial Natural Science Foundation of China (Grant No. LY18B020010) and the Foundation of Wenzhou Medical University Renji College (Grant RJRC14001) for financial support.

语种：英文

外文摘要：A Pd-catalyzed, native alpha-amino acid derivative-directed benzylic C-H bond arylation/oxidation with aryl iodides was developed. The natural amino acid auxiliary could serve as a desired building block for formation of 5-aryl-1,4-benzodiazepin-2-ones after removal of the trifluoroacetyl protecting group. The bifunctional reaction probably proceeded through a sequential benzylic arylation/oxidation process.