文献类型：期刊文献

英文题名：Folium nelumbinis (Lotus leaf) volatile-rich fraction and its mechanisms of action against melanogenesis in B16 cells

作者：Teng, Hui[1];Fan, Xiaoyun[1];Lv, Qiyan[1];Zhang, Qin[1];Xiao, Jianbo[1];Qian, Yuewei[1];Zheng, Baodong[1];Gao, Hui[2];Gao, Sihai[3];Chen, Lei[1]

机构：[1]Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Fujian, Peoples R China;[2]Shaoxing Univ, Dept Pharmacol, Coll Med, Shaoxing 312000, Zhejiang, Peoples R China;[3]Huazhong Univ Sci & Technol, Dept Cardiothorac & Vasc Surg, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China

年份：2020

卷号：330

外文期刊名：FOOD CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:000551370600004)、、EI(收录号：20202508839478)、Scopus(收录号：2-s2.0-85086358406)、WOS

基金：This work is supported by the National Natural Science Foundation of China (NSFC, Grant No. 31701520, 31801459), China Postdoctoral Science Foundation Funded Project (No. 2018M642551), the Funds for Distinguished Young Scientists (Grant No. kxjq17012) at Fujian agriculture and forestry university of China.

语种：英文

外文关键词：F. nelumbinis; Petroleum ether fraction; Volatile compound; Tyrosinase inhibition; B16 cell; Apoptosis

外文摘要：This study was aimed at determining the influence of Folium nelumbinis (Lotus leaf) extracts on melanogenesis in vitro models of melanoma cell line. The anticancer activity of four fractions, including petroleum ether (PEE), n-hexane (HE), ethanol (EE), and ethyl acetate (EAE) from F. nelumbinis on B16 cell lines (C57BL/6J melanoma cell), were evaluated after 24 and 48 h treatment. Results showed that PEE as well as volatile-rich fractions of linolenic acid and linolenic acid ethyl ester significantly (p < 0.05) reduced tyrosinase activity and melanin content in B16 melanoma cells model. Meanwhile, PEE and its primarily contained compound triggered apop-tosis of B16 cells in a dose-dependent way. These results demonstrated that PEE possessed effective activities against melanin and tyrosinase generations through the induction of apoptosis. Moreover, a relation between the volatile-rich fractions of F. nelumbinis and the anticancer effects was demonstrated as well.