文献类型：期刊文献

英文题名：The role of immune cells and associated immunological factors in the immune response to spinal cord injury

作者：Tang, Huaguo[1];Gu, Yuanjie[1];Jiang, Lei[1];Zheng, Gang[2];Pan, Zhuoer[3];Jiang, Xiugui[1]

机构：[1]Zhejiang Rongjun Hosp, Dept Hand & Foot Surg, Jiaxing, Peoples R China;[2]Shaoxing Univ, Dept Neurosurg, Cent Hosp, Jiaxing, Peoples R China;[3]Zhejiang Rongjun Hosp, Dept Orthoped, Jiaxing, Peoples R China

年份：2023

卷号：13

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：SCI-EXPANDED(收录号：WOS:000916514800001)、、Scopus(收录号：2-s2.0-85146506141)、WOS

语种：英文

外文关键词：spinal cord injury; immune response; immune cells; immune cytokines; therapeutic targets

外文摘要：Spinal cord injury (SCI) is a devastating neurological condition prevalent worldwide. Where the pathological mechanisms underlying SCI are concerned, we can distinguish between primary injury caused by initial mechanical damage and secondary injury characterized by a series of biological responses, such as vascular dysfunction, oxidative stress, neurotransmitter toxicity, lipid peroxidation, and immune-inflammatory response. Secondary injury causes further tissue loss and dysfunction, and the immune response appears to be the key molecular mechanism affecting injured tissue regeneration and functional recovery from SCI. Immune response after SCI involves the activation of different immune cells and the production of immunity-associated chemicals. With the development of new biological technologies, such as transcriptomics, the heterogeneity of immune cells and chemicals can be classified with greater precision. In this review, we focus on the current understanding of the heterogeneity of these immune components and the roles they play in SCI, including reactive astrogliosis and glial scar formation, neutrophil migration, macrophage transformation, resident microglia activation and proliferation, and the humoral immunity mediated by T and B cells. We also summarize findings from clinical trials of immunomodulatory therapies for SCI and briefly review promising therapeutic drugs currently being researched.