文献类型：期刊文献

英文题名：Reduced mechanical hypersensitivity by inhibition of the amygdala in experimental neuropathy: Sexually dimorphic contribution of spinal neurotransmitter receptors

作者：Wei, Hong[1];Chen, Zuyue[1,2];Lei, Jing[1,3];You, Hao-Jun[3];Pertovaara, Antti[1,4]

机构：[1]Univ Helsinki, Fac Med, Dept Physiol, Helsinki, Finland;[2]Shaoxing Univ, Sch Med, Dept Med Imaging, Shaoxing, Peoples R China;[3]Yanan Univ, Ctr Translat Med Res Sensory Motor Dis, Yanan, Peoples R China;[4]Univ Helsinki, Fac Med, Dept Physiol, POB 63, Helsinki 00014, Finland

年份：2022

卷号：1797

外文期刊名：BRAIN RESEARCH

收录：SCI-EXPANDED(收录号：WOS:000880093500001)、、Scopus(收录号：2-s2.0-85140289146)、WOS

基金：This study was financially supported by the Academy of Finland (# 315043) and the Sigrid Juselius Foundation, Helsinki, Finland.

语种：英文

外文关键词：Amygdala; Descending pain modulation; Peripheral neuropathy; Sex-difference

外文摘要：Here we studied spinal neurotransmitter mechanisms involved in the reduction of mechanical hypersensitivity by inhibition of the amygdaloid central nucleus (CeA) in male and female rats with spared nerve injury (SNI) model of neuropathy. SNI induced mechanical hypersensitivity that was stronger in females. Reversible blocking of the CeA with muscimol (GABAA receptor agonist) induced a reduction of mechanical hypersensitivity that did not differ between males and females. Following spinal co-administration of atipamezole (alpha 2-adrenoceptor antago-nist), the reduction of mechanical hypersensitivity by CeA muscimol was attenuated more in males than females. In contrast, following spinal co-administration of raclopride (dopamine D2 receptor antagonist) the reduction of hypersensitivity by CeA muscimol was attenuated more in females than males. The reduction of mechanical hypersensitivity by CeA muscimol was equally attenuated in males and females by spinal co-administration of WAY-100635 (5-HT1A receptor antagonist) or bicuculline (GABAA receptor antagonist). The CeA muscimol induced attenuation of ongoing pain-like behavior (conditioned place preference test) that was reversed by spinal co-administration of atipamezole in both sexes. The results support the hypothesis that CeA contributes to me-chanical hypersensitivity and ongoing pain-like behavior in SNI males and females. Disinhibition of descending controls acting on spinal alpha 2-adrenoceptors, 5-HT1A, dopamine D2 and GABAA receptors provides a plausible explanation for the reduction of mechanical hypersensitivity by CeA block in SNI. The involvement of spinal dopamine D2 receptors and alpha 2-adrenoceptors in the CeA muscimol-induced reduction of mechanical hypersen-sitivity is sexually dimorphic, unlike that of spinal alpha 2-adrenoceptors in the reduction of ongoing neuropathic pain.