文献类型：期刊文献

英文题名：A novel and practical synthetic route for the total synthesis of lycopene

作者：Shen, Runpu[1];Jiang, Xiaoyue[2];Ye, Weidong[2];Song, Xiaohua[2];Liu, Luo[2];Lao, Xuejun[2];Wu, Chunlei[1]

机构：[1]Shaoxing Univ, Dept Chem & Chem Engn, Shaoxing 312000, Zhejiang, Peoples R China;[2]Zhejiang Med Co Ltd, Xinchang Pharmaceut Factory, Xinchang 312500, Zhejiang, Peoples R China

年份：2011

卷号：67

期号：31

起止页码：5610

外文期刊名：TETRAHEDRON

收录：SCI-EXPANDED(收录号：WOS:000293109400012)、、Scopus(收录号：2-s2.0-79959764237)、WOS、CCR-EXPANDED(收录号：WOS:000293109400012)

语种：英文

外文关键词：Lycopene; Total synthesis; Wittig-Horner reaction

外文摘要：A novel route for the total synthesis of lycopene 1 is described. The synthesis is based on: (i) a condensation between 4,4-dimethoxy-3-methylbutanal 4 and methylenebisphosphonic acid tetraethyl ester 5, leading to the C6-phosphonate 6, followed by (ii) a modified Wittig-Horner reaction between 6 and 6-methyl-5-hepten-2-one 7 producing dimethoxy-3,5,9-triene 8, and (iii) another modified Wittig-Horner reaction between C15-phosphonate 2 and C10-triene dialdehyde 3 producing all-E-lycopene. The synthetic steps are easily operated and practical for the large-scale production. (C) 2011 Elsevier Ltd. All rights reserved.