文献类型：期刊文献

英文题名：Saikosaponin D: A potential therapeutic drug for osteoarthritis

作者：Jiang, Junsong[1];Meng, Yanfeng[2];Hu, Songfeng[3];Botchway, Benson O. A.[4];Zhang, Yong[1];Liu, Xuehong[1]

机构：[1]Shaoxing Univ, Dept Histol & Embryol, Med Coll, Shaoxing 312000, Zhejiang, Peoples R China;[2]Shaoxing Univ, Affiliated Hosp, Dept Orthoped, Shaoxing, Peoples R China;[3]Shaoxing Hosp Tradit Chinese Med, Dept Orthoped, Shaoxing, Peoples R China;[4]Zhejiang Univ, Inst Neurosci, Sch Med, Hangzhou, Peoples R China

年份：2020

卷号：14

期号：8

起止页码：1175

外文期刊名：JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE

收录：SCI-EXPANDED(收录号：WOS:000545863100001)、、EI(收录号：20215111339758)、Scopus(收录号：2-s2.0-85087650261)、WOS

基金：Public Technology Applied Research Projects Foundation of Shaoxing City, Grant/Award Number: 2018C30033; Scientific Research Projects of Zhejiang Education Department, Grant/Award Number: Y201839818

语种：英文

外文关键词：apoptosis; autophagy; chondrocyte; inflammation; osteoarthritis; PI3k; Akt; mTOR signaling pathway; Saikosaponin

外文摘要：Osteoarthritis is a degenerative joint disease. Currently, no effective therapeutic exists for osteoarthritis in the clinic setting. Inflammatory response and autophagy are key players in the occurrence and prognosis of osteoarthritis. In recent years, the regulation of inflammation and autophagy signal pathway has been touted as a potential treatment course for osteoarthritis. Saikosaponin D has anti-inflammatory and induces autophagy effects via inhibiting the nuclear transcription factor-kappa B, mTOR signaling pathways. Here in the report, we analyze and summarize recent evidences pertaining to the relationship between Saikosaponin and osteoarthritis. Published studies were scoured for in research databases, such as PubMed and Scopus with the keywords Saikosaponin and osteoarthritis. Phosphatidylinositol 3-kinase (PI3k)/Akt/mTOR signaling pathway is an important autophagy modulator, and can regulate chondrocytic autophagy, inflammation, and apoptosis. Saikosaponin D alleviates inflammation and regulates autophagy by inhibiting the PI3k/Akt/mTOR signaling pathway. Saikosaponin D could be a potential therapeutic drug for osteoarthritis.