文献类型：期刊文献

英文题名：A novel tanshinone IIA/chitosan solid dispersion: Preparation, characterization and cytotoxicity evaluation

作者：Luo, Chao[1];Wu, Weibin[2];Lin, Xinyu[1];Li, Yaoqi[1];Yang, Kai[3]

机构：[1]Shaoxing Univ, Dept Med & Hlth, Yuanpei Coll, Shaoxing 312000, Peoples R China;[2]Zhaoqing Med Coll, Dept Basic Med, Zhaoqing 526020, Peoples R China;[3]Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou Inst Resp Hlth,Guangdong Key Lab Vasc D, State Key Lab Resp Dis,Natl Clin Res Ctr Resp Dis, Guangzhou 510182, Guangdong, Peoples R China

年份：2019

卷号：49

起止页码：260

外文期刊名：JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

收录：SCI-EXPANDED(收录号：WOS:000457344000030)、、Scopus(收录号：2-s2.0-85057813167)、WOS

基金：The authors acknowledge the financial support from the Natural Science Foundation of Zhejiang Province (LQ16H310002) and the National Natural Science Foundation of China (81800057).

语种：英文

外文关键词：Tanshinone IIA; Chitosan; Solid dispersion; pH-responsive; Cytotoxicity

外文摘要：The objective of this study was to develop and evaluate a novel tanshinone IIA (TA)/chitosan (CS) solid dispersion (TA-CS-SD) to improve the bioavailability. Solid dispersion of tanshinone IIA with chitosan was prepared by a pH inversion method via the pH-responsive dissolution property of chitosan matrix. The in vitro dissolution study confirmed dramatically elevated dissolution rate of TA by solid dispersion approach, and the release mechanism exhibited pH-responsive performance. The solid dispersion was characterized by x-ray diffractometry (XRD), differential scanning calorimetry (DSC), fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Our results showed that TA existed in the form of microcrystal or superfine crystal in solid dispersion, and the reduction of crystallinity was correlated with the content of CS matrix. In vitro cytotoxicity study was performed in human non-small cell lung cancer A549 cell line by CCK-8 assay. Significant improvement in antitumor activity of TA in TA-CS-SD was achieved compared to the crystalline drug. These results indicated that, compared with free TA, TA-CS-SD demonstrated higher dissolution rate and bioactivity.