文献类型：期刊文献

英文题名：Developments in the Construction of Benzo[b]Thiophenes from 2-Alkynylthioanisoles by Electrophilic and Radical Cyclization Reactions

作者：Shang, Tianbo[1,2];Ma, Chao[1];Xie, Mengyu[1];Gao, Yuzhen[3];Cai, Tao[1,2]

机构：[1]Shaoxing Univ, Coll Chem & Chem Engn, Shaoxing 312000, Peoples R China;[2]Shaoxing Univ, Zhejiang Engn Res Ctr Fat Soluble Vitamin, Shaoxing 312000, Peoples R China;[3]Chinese Acad Sci, Fujian Inst Res Struct Matter, Fuzhou 350002, Peoples R China

年份：2024

外文期刊名：EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:001357855900001)、、Scopus(收录号：2-s2.0-85209774581)、WOS

基金：We gratefully thank the Shaoxing Basic Public Welfare Project (No. 2023A11003), and the Research Project of Shaoxing University (No. 2023LG003).

语种：英文

外文关键词：Benzo[b]thiophene; 5-endo-dig cyclization; 2-alkynylthioanisole; Electrophilic cyclization; Radical cyclization

外文摘要：Benzo[b]thiophene moieties are important skeletons which have been widely found in many natural products, pharmaceuticals, as well as functionalized materials. 2-Alkynylthioanisoles, a class of bifunctional compounds bearing methylthio and alkynyl groups, are easily accessible from Pd-catalyzed Sonogashira coupling between 2-halothioanisoles and terminal alkynes, which have been widely employed as synthons in the construction of benzo[b]thiophenes through an electrophilic or a radical pathway. This review summarizes the related developments with a particular focus on the reaction mechanism. We hope it will help in future research in this area and believe that with the discovery of new catalytic systems, the industrial synthesis of benzo[b]thiophenes from 2-alkynylthioanisoles will be achieved soon.