文献类型：期刊文献

英文题名：The Effect of Oxycodone on Post-operative Pain and Inflammatory Cytokine Release in Elderly Patients Undergoing Laparoscopic Gastrectomy

作者：Lao, Wei-long[1];Song, Qi-liang[2];Jiang, Zong-ming[2];Chen, Wen-di[2];Zheng, Xian-he[2];Chen, Zhong-hua[1,3]

机构：[1]Shaoxing Univ, Sch Med, Shaoxing, Peoples R China;[2]Shaoxing Peoples Hosp, Dept Anesthesia, Shaoxing, Peoples R China;[3]Shaoxing Univ, Dept Anesthesia, Affiliated Hosp 1, Shaoxing, Peoples R China

年份：2021

卷号：8

外文期刊名：FRONTIERS IN MEDICINE

收录：SCI-EXPANDED(收录号：WOS:000696547200001)、、Scopus(收录号：2-s2.0-85115004865)、WOS

基金：This study was supported by Zhejiang Medical Science and Technology Program (2016KYA179) and Shaoxing Health Science and Technology Program (2017CX009).

语种：英文

外文关键词：oxycodone; post-operative analgesia; inflammatory cytokine; laparoscope; gastric cancer

外文摘要：Background: To evaluate the effect of oxycodone on post-operative pain and inflammation in elderly patients undergoing laparoscopic gastrectomy.

Methods: Sixty patients who were of both sexes, American Society of Anesthesiologists Physical Status (ASA-PS) Class I or II, over 65 years of age and undergoing an elective laparoscopic radical gastrectomy were randomly divided into two groups: an oxycodone group (Group O) including 20 males and 10 females and a sufentanil group (Group S) including 21 males and 9 females. The post-operative analgesia regimen was as follows: 40 mg of parecoxib sodium and 0.1 mg/kg of oxycodone was intravenously injected into Group O before the abdomen closure, while 40 mg of parecoxib sodium and 0.1 mu g/kg of sufentanil was injected intravenously into Group S. Both groups were infiltrated with 20 ml of 1% ropivacaine at the end of the operation. The level of serum IL-6 and IL-10 were assayed immediately at the following timepoints: at the conclusion of surgery (T1), 1 h (T2), 6 h (T3), and 24 h (T4) after the completion of the surgery. The numerical rating scale (NRS), the Ramsay sedation score, analgesic-related adverse events, post-operative pulmonary inflammation events and the post-operative stay were recorded.

Results: Compared with Group S, the serum IL-6 concentrations of Group O decreased at T-3 and T-4, while the serum IL-10 concentrations increased (P < 0.05). In Group O, the serum IL-6 concentrations at T-3 and T-4 were lower than those at T-1 (P < 0.05). The incidence of post-operative nausea and vomiting (PONV) and pulmonary inflammation in Group O was lower than that in Group S (P < 0.05). At each time point, the NRS of visceral pain in Group O was lower than that in Group S. At 6 and 24 h after extubation, the NRS of incision pain in Group O was lower than that in Group S (P < 0.05).

Conclusion: Oxycodone can regulate the level of inflammatory cytokines and reduce post-operative inflammatory response.