文献类型：期刊文献

英文题名：Identification of risk factors for disseminated cryptococcosis in non-hiv patients: a retrospective analysis

作者：Zhang, Fan[1];Zhou, Yiqing[2];Tang, Xiaoqi[1];Li, Minghui[2]

机构：[1]Shaoxing Univ, Sch Med, Shaoxing 312000, Zhejiang, Peoples R China;[2]Shaoxing Peoples Hosp, Dept Infect Dis, 568 Zhongxing Rd, Shaoxing 312000, Peoples R China

年份：2023

卷号：28

期号：1

外文期刊名：EUROPEAN JOURNAL OF MEDICAL RESEARCH

收录：SCI-EXPANDED(收录号：WOS:001127849500001)、、Scopus(收录号：2-s2.0-85180239712)、WOS

语种：英文

外文关键词：Pulmonary cryptococcosis; Cryptococcal meningoencephalitis; Disseminated cryptococcosis; Risk factor

外文摘要：Objective This study aimed to investigate the potential risk factors associated with disseminated cryptococcosis in HIV-negative individuals.Methods A total of 106 HIV-negative patients with cryptococcal disease were enrolled. The observation group consisted of patients with disseminated cryptococcosis (DC), whereas the control groups included patients with pulmonary cryptococcosis (PC) and cryptococcal meningitis (CM). Univariate and multivariate logistic regression algorithms were used to explore the significant clinical and laboratory characteristics that affect the progression of cryptococcal infections. Finally, receiver operating characteristics (ROC) curves are applied to assess the diagnostic value of identified risk factors.Results Of the 106 patients, 57 were diagnosed with pulmonary cryptococcosis, 22 with cryptococcal meningitis, and 27 with disseminated cryptococcosis. The logistic regression equation included five variables: diabetes, decompensated liver cirrhosis, long-term use of immunosuppressive agents, decreased serum albumin level, and elevated plasma cytokine IL-10 level. The ROC curves showed that albumin (AUC > 0.7), IL-10 (AUC > 0.7) and decompensated liver cirrhosis (AUC > 0.6) have relatively high diagnostic capacity in predicting the progression of Cryptococcus.Conclusion This study identified elevated IL-10 levels as an independent risk factor for developing disseminated cryptococcosis in the control groups. Furthermore, decompensated liver cirrhosis and decreased serum albumin independently affected the progression of cryptococcosis in the CM and PC groups, respectively.