文献类型：期刊文献

英文题名：Polyhexamethylene Biguanide Functionalized Hyperbranched Polymers Enhance Their Antimicrobial Activities

作者：Meng, Xu[1,3];Wang, Bin[3];Liang, Liping[2];Liu, Bailing[3]

机构：[1]Shaoxing Univ, Coll Text & Garment, Shaoxing, Peoples R China;[2]Shaoxing Univ, Coll Life Sci, Shaoxing, Peoples R China;[3]Chinese Acad Sci, Chengdu Inst Organ Chem, Beijing 100864, Peoples R China

年份：2017

卷号：41

期号：2

起止页码：212

外文期刊名：POLYMER-KOREA

收录：SCI-EXPANDED(收录号：WOS:000398245000007)、、Scopus(收录号：2-s2.0-85018788894)、WOS

基金：The authors gratefully acknowledge the financial support from the Opening Project of Zhejiang Key Laboratory of Clean Dyeing and Finishing Technology (Grant No. 1402), Zhejiang Provincial Natural Science Foundation of China (Grant No. LQ15E080003), Zhejiang provincial Public Welfare Project (Grant No. 2017C31114), Shaoxing public welfare project (Grant No. 2015B70006), and the scientific research start-up funding of Shaoxing University (Grant No. 20145023, 20145033), School Research project Shaoxing University (Grant No. 2014LG1010), as well the helpness from Professor Zhengyong Qian and MS Ying Qu of Sichuan University.

语种：英文

外文关键词：hyperbranched polymer; polyhexamethylene biguanide; antimicrobial activity; antimicrobial mechanism

外文摘要：Hyperbranched antibacterials show much more potential performances than their small molecules due to unique structure. Polyhexamethylene biguanide (PHMB) functionalized hyperbranched poly(amide-PHMB)s (DPBs) were prepared and their antibacterial properties were investigated using several techniques. The results showed that Gram-positive organisms were more susceptible than Gram-negative bacteria for DPBs, N-1, N-3, N-5-tris(2-aminoethyl)benzene-1,3,5-tri-carboxamide (DT) and PHMB. DPBs had better comprehensive properties than DT and PHMB, and the best one was DPB1. SEM and AFM were utilized to investigate the interactions between DPB1 and bacterial membranes of E. coli. The mode of action of DPB1 was revealed by the morphological images, which was consistent with bactericidal mechanism of cationic antibacterial agents.