文献类型：期刊文献

英文题名：Animal and Organoid Models of Liver Fibrosis

作者：Bao, Yu-long[1];Wang, Li[1];Pan, Hai-ting[1];Zhang, Tai-ran[1];Chen, Ya-hong[2];Xu, Shan-jing[3];Mao, Xin-li[3,4,5];Li, Shao-wei[3,4,5]

机构：[1]Inner Mongolia Med Univ, Coll Basic Med, Hohhot, Peoples R China;[2]Wenzhou Med Univ, Hlth Management Ctr, Taizhou Hosp Zhejiang Prov, Linhai, Peoples R China;[3]Shaoxing Univ, Sch Med, Shaoxing, Peoples R China;[4]Wenzhou Med Univ, Key Lab Minimally Invas Techn & Rapid Rehabil Dig, Taizhou Hosp Zhejiang Prov, Linhai, Peoples R China;[5]Wenzhou Med Univ, Dept Gastroenterol, Taizhou Hosp Zhejiang Prov, Linhai, Peoples R China

年份：2021

卷号：12

外文期刊名：FRONTIERS IN PHYSIOLOGY

收录：SCI-EXPANDED(收录号：WOS:000659067900001)、、Scopus(收录号：2-s2.0-85107595764)、WOS

基金：This work was supported in part by the Program of Inner Mongolia Autonomous Region Tumor Biotherapy Collaborative Innovation Center, Medical Science and Technology Project of Zhejiang Province (2021PY083), Program of Taizhou Science and Technology Grant (20ywb29), Major Research Program of Taizhou Enze Medical Center Grant (19EZZDA2), Key Technology Research and Development Program of Zhejiang Province (2019C03040), and Open Fund of Key Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor of Zhejiang Provinces (21SZDSYS01 and 21SZDSYS09).

语种：英文

外文关键词：liver; fibrosis; animal; organoid; model

外文摘要：Liver fibrosis refers to the process underlying the development of chronic liver diseases, wherein liver cells are repeatedly destroyed and regenerated, which leads to an excessive deposition and abnormal distribution of the extracellular matrix such as collagen, glycoprotein and proteoglycan in the liver. Liver fibrosis thus constitutes the pathological repair response of the liver to chronic injury. Hepatic fibrosis is a key step in the progression of chronic liver disease to cirrhosis and an important factor affecting the prognosis of chronic liver disease. Further development of liver fibrosis may lead to structural disorders of the liver, nodular regeneration of hepatocytes and the formation of cirrhosis. Hepatic fibrosis is histologically reversible if treated aggressively during this period, but when fibrosis progresses to the stage of cirrhosis, reversal is very difficult, resulting in a poor prognosis. There are many causes of liver fibrosis, including liver injury caused by drugs, viral hepatitis, alcoholic liver, fatty liver and autoimmune disease. The mechanism underlying hepatic fibrosis differs among etiologies. The establishment of an appropriate animal model of liver fibrosis is not only an important basis for the in-depth study of the pathogenesis of liver fibrosis but also an important means for clinical experts to select drugs for the prevention and treatment of liver fibrosis. The present study focused on the modeling methods and fibrosis characteristics of different animal models of liver fibrosis, such as a chemical-induced liver fibrosis model, autoimmune liver fibrosis model, cholestatic liver fibrosis model, alcoholic liver fibrosis model and non-alcoholic liver fibrosis model. In addition, we also summarize the research and application prospects concerning new organoids in liver fibrosis models proposed in recent years. A suitable animal model of liver fibrosis and organoid fibrosis model that closely resemble the physiological state of the human body will provide bases for the in-depth study of the pathogenesis of liver fibrosis and the development of therapeutic drugs.