文献类型：期刊文献

中文题名：亚临床甲状腺功能减退症与贫血的相关性研究

英文题名：Relationship between subclinical hypothyroidism and anemia

作者：杨国军[1,2];李红[1]

机构：[1]浙江大学医学院附属邵逸夫医院内分泌科;[2]绍兴文理学院附属医院内分泌科

年份：2015

卷号：0

期号：3

起止页码：216

中文期刊名：浙江医学

外文期刊名：Zhejiang Medical Journal

收录：CSTPCD

语种：中文

中文关键词：亚临床甲减;红细胞;血红蛋白;贫血

外文关键词：Subclinical hypothyroidism;Red blood cell;Hemoglobin;Anemia

中文摘要：目的：探讨亚临床甲状腺功能减退症（简称亚临床甲减）与贫血之间的关系及其临床意义。方法以2011年1月至2013年6月健康体检发现的193例亚临床甲减患者为研究对象（简称亚临床甲减组），选取同期进行健康体检的772例甲状腺功能正常者作为对照（简称甲功正常组），比较两组受试者甲状腺功能、血常规、肝肾功能、血糖及血脂等各项指标的差异，以及两组间贫血患病率的差异，并分析贫血患病的危险因素。结果与甲功正常组比较，亚临床甲减组患者的血红蛋白和红细胞均明显降低（均P＜0.05）；球蛋白则高于甲功正常组（P＜0.05）；其余各项指标间比较均无统计学差异（均P＞0.05）。与甲功正常组比较，亚临床甲减组的贫血患病率增高（6.2% vs 2.7%，P＜0.05）。Pearson相关分析发现，在亚临床甲减和甲功正常组中，FT3、FT4水平与血红蛋白和红细胞水平呈明显正相关（r=0.364、0.328、0.288、0.243，均P＜0.01）。logistic回归分析显示亚临床甲减（OR=2.440，95%CI=1.100-5.411，P＜0.05）和低FT4（OR=0.793，95%CI=0.633-0.993，P＜0.05）是贫血患病的独立危险因素。结论亚临床甲减可引起患者外周血红细胞和血红蛋白的降低，亚临床甲减患者贫血的患病率明显增高；亚临床甲减和低FT4是贫血患病的独立危险因素。

外文摘要：Objective To investigate the relationship between subclinical hypothyroidism and anemia. Methods One hundred and ninety three cases with subclinical hypothyroidism detected in Affiliated Hospital of Shaoxing University from January 2011 to June 2013 were enrol ed in the study （case group） and 772 subjects with normal thyroid function served as control group. The thyroid function, blood routine, liver and kidney function, blood lipids and other indicators, as wel as the prevalence of anemia were compared between two groups;and the risk factors of anemia were analyzed. Results Compared with control group, the hemoglobin levels and red blood cel s in case group were decreased, and globulin（G） was increased significantly （both P〈0.05）;however, there was no significant difference in other indexes between two groups （P〉0.05）. The prevalence of anemia in case group was higher than that of control group （6.2%VS 2.7%, P〈0.05）. Pearson correlation analysis showed that FT3 and FT4 were positively correlated with hemoglobin（Hb） and red blood cel （RBC）（r=0.364, 0.328, 0.288, 0.243, al P〈0.01）. Logistic regres-sion analysis showed that subclinical hypothyroidism（OR=2.440, 95%CI=1.100-5.411, P〈0.05） and low FT4 （OR=0.793, 95%CI=0.633-0.993, P〈0.05） were independent risk factors of anemia. Conclusion The study shows that the prevalence of anemia is significantly higher in patients with subclinical hypothyroidism, subclinical hypothyroidism and low FT4 are independent risk factors for anemia.