文献类型：期刊文献

英文题名：Curcumin Can Activate the Nrf2/HO-1 Signaling Pathway and Scavenge Free Radicals in Spinal Cord Injury Treatment

作者：Jin, Wenlong[1];Botchway, Benson O. A.[2];Liu, Xuehong[1]

机构：[1]Shaoxing Univ, Med Coll, Shaoxing, Peoples R China;[2]Zhejiang Univ, Sch Med, Hangzhou, Peoples R China

年份：2021

卷号：35

期号：7

起止页码：576

外文期刊名：NEUROREHABILITATION AND NEURAL REPAIR

收录：SCI-EXPANDED(收录号：WOS:000651562400001)、、Scopus(收录号：2-s2.0-85105919762)、WOS

基金：The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Natural Science Foundation of Zhejiang Province (No. LY19H170001) and the General research project of Zhejiang Provincial Department of Education (No. Y202044556).

语种：英文

外文关键词：curcumin; Nrf2; HO-1 signaling pathway; antioxidant; spinal cord injury

外文摘要：Spinal cord injury (SCI) is a devastating event that often leads to permanent neurological deficits. Evidence from emerging studies has implicated oxygen-derived free radicals and high-energy oxidants as mediators of secondary SCI. Therefore, targeting these mediators using antioxidants could be beneficial for the disease. Several signaling pathways, such as the nuclear factor erythroid-2-related factor 2/heme oxygenase 1 (Nrf2/HO-1), have been associated with the regulation of some pathophysiological features of SCI. Curcumin is a plant medicinal agent whose diverse pharmacological properties have been extensively investigated and reported, notably its ability to curtail inflammatory damage by inhibiting the nuclear factor-kappa-light-chain-enhancer of activated B cells. In this review, we analyze the role of curcumin in activating Nrf2/HO-1 and scavenging free radicals to repair SCI. With its minimal side effects, curcumin could be a potential therapy for SCI treatment.