文献类型：期刊文献

英文题名：Role of AMP activated protein kinase signaling pathway in intestinal development of mammals

作者：Meng, Xiaofang[1];Zhang, Yong[1];Botchway, Benson O. A.[2];Zhou, Jingying[1];Xu, Luyao[1];Liu, Xuehong[1]

机构：[1]Shaoxing Univ, Med Coll, Dept Histol & Embryol, Shaoxing 312000, Zhejiang, Peoples R China;[2]Zhejiang Univ Sch Med, Inst Neurosci, Hangzhou, Zhejiang, Peoples R China

年份：2018

卷号：220

起止页码：51

外文期刊名：ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

收录：SCI-EXPANDED(收录号：WOS:000449309800006)、、Scopus(收录号：2-s2.0-85051135808)、WOS

基金：This work was supported by the scientific research project of Zhejiang Provincial Education Department (no. Y200805569, no. Y201018535).

语种：英文

外文关键词：AMP activated protein kinase (AMPK); Inflammatory disease; Signaling pathway; Intestine; Development; Mammals

外文摘要：Intestinal tract is an important digestive organ, which takes on the functions of nutrient absorption, bile and metabolic waste excretion. Impaired intestinal barrier function might lead to inflammatory and intestinal diseases. Structure and function of intestinal tract is closely related to differentiation and development of intestinal cells. Differentiation and development of intestinal cells are coordinated and regulated via signaling pathways such as adenosine monophosphate-activated protein kinase (AMPK), Wnt and mammalian target of rapamycin (mTOR) signaling pathways. AMPK signaling pathway plays an important role in energy balance of intestinal cells and provides a theoretical basis for the treatment of intestinal diseases. Herein, we systematically summarizes the respective morphological characteristics of intestinal development in mammals, molecular mechanisms of intestinal development, AMPK signaling pathway and AMPK signaling pathway involved in intestinal tissue cell development. (C) 2018 Elsevier GmbH. All rights reserved.