文献类型：期刊文献

英文题名：Conditional survival of patients with primary bone lymphoma of the spine: how survival changes after initial diagnosis

作者：Zheng, Gang[1];Yang, Zhihao[1];Qian, Hui[1];Huang, Hua[1];Gu, Zhiwei[1]

机构：[1]Shaoxing Univ, Shaoxing Cent Hosp, Dept Neurosurg, Cent Hosp, Shaoxing, Zhejiang, Peoples R China

年份：2024

卷号：14

外文期刊名：FRONTIERS IN ONCOLOGY

收录：SCI-EXPANDED(收录号：WOS:001222163100001)、、Scopus(收录号：2-s2.0-85193038975)、WOS

基金：We applaud the Surveillance, Epidemiology and End Results (SEER) Program's remarkable contribution toward the provision of superior open-access materials for academic researchers.

语种：英文

外文关键词：primary bone lymphoma of the spine; conditional survival; nomogram; survival estimation; SEER primary bone lymphoma of the spine; SEER

外文摘要：Background The current survival prediction methodologies for primary bone lymphoma (PBL) of the spine are deficient. This study represents the inaugural utilization of conditional survival (CS) to assess the outcome of this disease. Moreover, our objective was to devise a CS-based nomogram for predicting overall survival (OS) in real-time for spinal PBL.Methods Patients with PBL of the spine diagnosed between January 2000 and December 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. The OS was determined through the Kaplan-Meier method. The CS characteristic of patients with spinal PBL was delineated, with the CS being estimated utilizing the formula: CS(alpha|beta) = OS(alpha+beta)/OS(beta). CS(alpha|beta) denotes the probability of additional alpha-year survivorship, assuming the patient has already survived beta years after the time of observation. Three methods including univariate Cox regression, best subset regression (BSR) and the least absolute shrinkage and selection operator (LASSO) regression were used to identify predictors for CS-based nomogram construction.Results Kaplan-Meier analysis was executed to determine the OS rate for these patients, revealing a survival rate of 68% and subsequently 63% at the 3-year and 5-year mark respectively. We then investigated the CS patterning exhibited by these patients and discovered the survival of PBL in the spine progressively improved with time. Meanwhile, through three different prognostic factor selection methods, we identified the best predicter subset including age, tumor histology, tumor stage, chemotherapy and marital status, for survival prediction model construction. Finally, we successfully established and validated a novel CS-based nomogram model for real-time and dynamic survival estimation. Moreover, we further designed a risk stratification system to facilitate the identification of high-risk patients.Conclusions This is the first study to analyze the CS pattern of PBL of the spine. And we have also developed a CS-based nomogram that provide dynamic prognostic data in real-time, thereby aiding in the formulation of personalized treatment strategies in clinical practice.