文献类型：期刊文献

英文题名：HER-2, ER, PR status concordance in primary breast cancer and corresponding metastatic lesion in lymph node in Chinese women

作者：Li, Min Hua[1,2];Hou, Chuan Ling[1,2];Wang, Cheng[1,2];Sun, Ai Jing[3]

机构：[1]Zhejiang Univ, Shaoxing Peoples Hosp, Dept Pathol, Shaoxing, Zhejiang, Peoples R China;[2]Zhejiang Univ, Shaoxing Hosp, Shaoxing, Zhejiang, Peoples R China;[3]Shaoxing Univ, Sch Med, Dept Pathol, Shaoxing, Zhejiang, Peoples R China

年份：2016

卷号：212

期号：4

起止页码：252

外文期刊名：PATHOLOGY RESEARCH AND PRACTICE

收录：SCI-EXPANDED(收录号：WOS:000375500300003)、、Scopus(收录号：2-s2.0-84958279926)、WOS

基金：This study was supported by a grant from Zhejiang Provincial Key Medical Discipline Construction of China (no. GJSX-010-004)

语种：英文

外文关键词：ER; PR; HER-2; Breast cancer; Metastatic lymph nodes

外文摘要：Aims and background: To compare the expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) in the primary site and the metastatic lesion of lymph nodes in invasive breast cancer for investigating whether the expression of these biomarkers in the primary site could act as a surrogate to the lymphatic metastatic lesion in the same patient. Methods: In lymphatic metastatic lesion and corresponding primary lesion of 107 cases of invasive breast cancer, ER and PR statuses were assessed by immunohistochemistry (IHC). HER-2 expression level was evaluated by IHC and/or fluorescence in situ hybridization (FISH). Results: In the primary lesions, 43.9% were ER positive; 46.7% were PR positive; 34.6% were HER-2 positive. In corresponding lymphatic metastatic lesions, the HER-2 status was concordant in 90 patients; 9 patients were diagnosed positive in metastatic lesion while negative in primary lesion; 8 patients were negative in metastatic lesion while positive in primary site (agreement, 84.1%; kappa = 0.647). A change in ER status was observed in 24 cases: 17 cases positive in metastatic site while negative in primary site; 7 cases negative in metastatic site while positive in primary site (agreement, 77.6%; kappa = 0.534). PR status discordance between the primary lesion and the metastatic regional lymph nodes was reported in 19 cases (agreement, 82.2%; kappa = 0.640). Conclusions: This study revealed that there was only a moderate concordance of ER, PR and HER-2 status between primary tumors and metastatic lymph nodes. These results indicate that it was inappropriate to predict the status of ER, PR and HER-2 in metastatic lymph nodes based on the results of evaluation of that in primary lesions. (C) 2015 Elsevier GmbH. All rights reserved.