文献类型：期刊文献

英文题名：Curcumin can improve Parkinson's disease via activating BDNF/PI3k/Akt signaling pathways

作者：Jin, Tian[1];Zhang, Yong[1];Botchway, Benson O. A.[2];Zhang, Jian[3];Fan, Ruihua[4];Zhang, Yufeng[1];Liu, Xuehong[1,5]

机构：[1]Shaoxing Univ, Med Coll, Dept Histol & Embryol, Shaoxing, Zhejiang, Peoples R China;[2]Zhejiang Univ, Inst Neurosci, Sch Med, Hangzhou, Peoples R China;[3]Shaoxing Univ, Med Coll, Dept Pharmacol, Shaoxing, Zhejiang, Peoples R China;[4]Shaoxing Univ, Sch Life Sci, Shaoxing, Zhejiang, Peoples R China;[5]Shaoxing Univ, Med Coll, Dept Histol & Embryol, Shaoxing 312000, Zhejiang, Peoples R China

年份：2022

卷号：164

外文期刊名：FOOD AND CHEMICAL TOXICOLOGY

收录：SCI-EXPANDED(收录号：WOS:000828323500003)、、Scopus(收录号：2-s2.0-85130338944)、WOS

语种：英文

外文关键词：Parkinson?s disease; Curcumin; Brain-derived neurotrophic factor; PI3k; Akt signaling pathway; Neurodegenerative diseases

外文摘要：Parkinson's disease is a common progressive neurodegenerative disease, and presently has no curative agent. Curcumin, as one of the natural polyphenols, has great potential in neurodegenerative diseases and other different pathological settings. The brain-derived neurotrophic factor (BDNF) and phosphatidylinositol 3 kinase (PI3k)/protein kinase B (Akt) signaling pathways are significantly involved nerve regeneration and antiapoptotic activities. Currently, relevant studies have confirmed that curcumin has an optimistic impact on neuroprotection via regulating BDNF and PI3k/Akt signaling pathways in neurodegenerative disease. Here, we summarized the relationship between BDNF and PI3k/Akt signaling pathway, the main biological functions and neuroprotective effects of curcumin via activating BDNF and PI3k/Akt signaling pathways in Parkinson's disease. This paper illustrates that curcumin, as a neuroprotective agent, can delay the progression of Parkinson's disease by protecting nerve cells.