文献类型：期刊文献

英文题名：Intelligent transdermal nanoparticles as synergizing advanced delivery systems for precision therapeutics

作者：Guo, Zhouying[1];Zhang, Yi'nan[2];Zhao, Man[3];Zhang, Wenyuan[3];Li, Xiaofang[5];Zhou, Fang[5];Peng, Haisheng[4,5];Wang, Qun[6];Chen, Zhiwei[1]

机构：[1]Zhejiang Chinese Med Univ, Wenzhou Hosp Integrated Tradit Chinese & Western, 75 Jinxiu Rd, Wenzhou 325000, Peoples R China;[2]Zhejiang Chinese Med Univ, Sch Clin Med 1, 548 Binwen Rd, Hangzhou 310051, Peoples R China;[3]Harbin Med Univ, Dept Pharmaceut, Daqing Branch, 39 Xin Yang Rd, Daqing 163319, Peoples R China;[4]Shaoxing Univ, Med Coll, 508 Huancheng Western Rd, Shaoxing 312099, Peoples R China;[5]Shaoxing Univ, Tradit Chinese Med Hosp Zhuji, 521 Donger Rd, Zhuji 311800, Peoples R China;[6]Iowa State Univ, Dept Chem & Biol Engn, Ames, IA 50011 USA

年份：2025

卷号：34

外文期刊名：MATERIALS TODAY BIO

收录：SCI-EXPANDED(收录号：WOS:001562074600001)、、EI(收录号：20253619102493)、Scopus(收录号：2-s2.0-105014755618)、WOS

基金：Dr. Peng thanks the support from the Joint fund of Shaoxing University and Shaoxing Institute of Zhejiang University (2023LHLG007) and the National Natural Science Foundation of China (no. 81671814) .

语种：英文

外文关键词：Transdermal drug delivery; Nanoplatforms; Physical enhancement technologies; Integrated strategies; Clinical applications; Artificial intelligence

外文摘要：Transdermal drug delivery systems (TDDS) represent a non-invasive approach to achieve controlled drug release through the skin barrier, offering stable plasma concentrations while avoiding gastrointestinal and hepatic metabolism. However, the skin barrier poses physical challenges, making it difficult for most drugs to penetrate deep tissues using TDDS. This review systematically summarizes the research progress in nanocarrier design, physical technology application, and artificial intelligence (AI)-driven TDDS optimization design aimed at overcoming the key problem of skin barrier penetration. An in-depth analysis of nanocarriers, such as soft vesicles, nanoemulsions, rigid nanoparticles, and physically assisted enhancement technologies, and AI-driven research on skin penetration enhancement in TDDS was summarized. An integrated technical framework demonstrates how microneedle arrays, iontophoresis, electroporation, and photoporation synergize with nanoparticles to achieve spatiotemporally controlled transdermal drug delivery. Additionally, the review emphasizes the clinical application potential of these integrated technologies and offers a comprehensive, multidimensional perspective to advance innovation in TDDS.