文献类型：期刊文献

中文题名：2-氯乙酰胺与硫脲绿色合成4-噻唑啉酮的反应研究

英文题名：A Novel and Green Method for the Synthesis of 4-Thiazolidinones with the Sources of 2-Chloroacetamide and Thioureas

作者：赵华绒[1];王玲[1];王昱丹[2]

机构：[1]浙江大学化学系;[2]绍兴文理学院化学化工学院

年份：2014

卷号：34

期号：4

起止页码：761

中文期刊名：有机化学

外文期刊名：Chinese Journal of Organic Chemistry

收录：SCI-EXPANDED(收录号：WOS:000336107900015)、CSTPCD、、北大核心2011、Scopus(收录号：2-s2.0-84900468445)、WOS、北大核心、CSCD、CSCD2013_2014

基金：Project supported by the Natural Science Foundation of Zhejiang Province (Nos. LY12B02015, Y4080234).

语种：中文

中文关键词：4-噻唑啉酮;2-氯乙酰胺;离子液体;机理;绿色

外文关键词：4-thiazolidinones; 2-chloroacetamide; ionic liquid; mechanism; green

中文摘要：首次报道了一种在离子液体中以2-氯乙酰胺与取代硫脲为原料,脱氨合成4-噻唑啉酮类化合物的新方法,并对其机理进行了探讨.通过实验表明该方法具有反应时间短,底物适应性广,原子经济性好,原料易得,收率较高,环境友好,产物易于分离纯化等特点,为4-噻唑啉酮类化合物的合成提供了一种新途径.

外文摘要：A novel, green synthetic method for 4-thiazolidinones in the ionic liquids was reported. 4-Thiazolidinones were prepared with the sources of substituted thioureas and 2-chloroacetamide in the ionic liquids. This method offers several ad- vantages like high yield, short reaction time and mild reaction conditions. The reaction mechanism was studied and the result showed that ammonia was removed in the reaction, which was the first reported.