文献类型：期刊文献

英文题名：A phosphomolybdenum blue nano-photothermal agent with dual peak absorption and biodegradable properties based on ssDNA in near-infrared photothermal therapy for breast cancer

作者：Fang, Baoru[1,2];Geng, Siqi[1,2];Wang, Ke[1,2];Wang, Fang[2,3];Zhou, Yiqing[2];Qin, Jiaying[2];Luo, Shengnan[1];Chen, Yanping[1,2];Yu, Zhangsen[1,2]

机构：[1]Shaoxing Univ, Sch Life & Environm Sci, Shaoxing 312000, Zhejiang, Peoples R China;[2]Shaoxing Univ, Med Sci Res Ctr, Sch Med, Lab Nanomed, Shaoxing 312000, Zhejiang, Peoples R China;[3]Wenzhou Med Univ, Clin Med Coll 1, Wenzhou 325000, Zhejiang, Peoples R China

年份：2025

外文期刊名：NANOSCALE HORIZONS

收录：SCI-EXPANDED(收录号：WOS:001411152300001)、、EI(收录号：20250617817535)、Scopus(收录号：2-s2.0-85216851499)、WOS

基金：This work was financially supported by the project of Zhejiang Provincial Natural Science Foundation (LTGY23H020002, LTGY24H030003), the Science and Technology Plan in Shaoxing City (2022A14026), the Medical and Health Science and Technology Plan Project of Zhejiang Province (2024KY495), Medical and Health Science and Technology Plan Project of Shaoxing (2022KY075).

语种：英文

外文关键词：Electrophysiology - Laser ablation - Laser beams - Laser safety - Nanoparticles - Oncology - Photodegradation - Photolysis - Physiological models - Tissue - Urology

外文摘要：Photothermal therapy (PTT) stands as an emerging and promising treatment modality and is being developed for the treatment of breast cancer, prostate cancer, and a series of superficial tumors. This innovative approach harnesses photothermal agents (PTAs) that convert near-infrared light (NIR) energy into heat, efficiently heating and ablating localized lesion tissue. Notably, the low scattering of NIR-II (1000-1500 nm) band light within biological tissue ensures superior penetration depth, surpassing that of NIR I (700-900 nm) band light. Consequently, developing PTAs with excellent absorption performance and biocompatibility in the NIR-II band has attracted significant attention in photothermal therapy research. We successfully synthesized phosphomolybdenum blue (PMB) nanoparticles using single-strand DNA (ssDNA) as a template in this innovative study. Subsequently, we delved into this material's absorption characteristics and photothermal properties across the NIR-I and NIR-II spectral regions. Furthermore, we evaluated the therapeutic efficacy of PMB on 4T1 cells and tumor-bearing mouse models of breast cancer. Our findings revealed that PMB not only exhibits remarkable biocompatibility but also possesses stellar photothermal performance. Specifically, under 808 nm and 1064 nm laser irradiation, PMB achieved photothermal conversion efficiencies of 21.37% and 28.84%, respectively. Notably, compared to 808 nm laser irradiation, even when transmitting through a 2 mm thick tumor tissue homogenate, the 1064 nm laser irradiation maintained a robust tumor ablation effect. What's more, PMB possesses critical pH-responsive degradation properties. For instance, PMB nanoparticles degrade rapidly under physiological conditions (pH 7.2-7.4) while degrading slower in the acidic tumor microenvironment (pH 6.0-6.9). This unique characteristic significantly mitigates the systemic toxicity of PMB and enhances the safety of photothermal therapy implementation. Moreover, our study represents the first instance of utilizing ssDNA as a template for synthesizing a PMB nano photothermal agent and demonstrating its exceptional tumor thermal ablation efficacy. This groundbreaking work offers novel insights into the development of safe, efficient, and pH-responsive photothermal agents for cancer therapy.