文献类型：期刊文献

英文题名：Mechanochemical deprotection of t-butoxycarbonyl (Boc) group using basic alumina

作者：Tian, Kaidi[1];Cai, Tingna[1];Zhu, Zedong[1];Cheng, Kai[1];Yu, Lemao[2];Li, Yong[1,3]

机构：[1]Shaoxing Univ, Zhejiang Key Lab Alternat Technol Fine Chem Proc, Shaoxing 312000, Peoples R China;[2]Shaoxing Univ, Green Pharmaceut & Proc Res Ctr, Shaoxing 312000, Peoples R China;[3]Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Tianjin 300350, Peoples R China

年份：2024

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:001310013800001)、、EI(收录号：20243817055836)、Scopus(收录号：2-s2.0-85204155785)、WOS

基金：Financial support was provided by the National Natural Science Foundation of China (Grant No. 21801167) and the State Key Laboratory of Medicinal Chemical Biology, NanKai University (Grant No. 2024001).

语种：英文

外文摘要：A solvent-free, operationally simple, and chemoselective mechanochemical method for t-butoxycarbonyl (Boc) deprotection is described. In a planetary ball mill, N-Boc groups from protected heterocycles, amides, and anilines, as well as O-Boc groups from carbonates, can be removed selectively, using basic alumina. This high-yielding protocol avoids tedious extraction and column chromatography.