文献类型：期刊文献

中文题名：可见光诱导铁催化氮杂环的羟甲基化

英文题名：Visible-Light Induced Iron-Catalyzed Hydroxymethylation of N-Heterocycles

作者：傅艳华[1];徐畅[1];张超[1];王怡莎[1];冯高峰[1]

机构：[1]绍兴文理学院、浙江省精细化学品绿色替代技术研究重点实验室,浙江绍兴312000

年份：2024

卷号：44

期号：7

起止页码：2265

中文期刊名：有机化学

外文期刊名：Chinese Journal of Organic Chemistry

收录：SCI-EXPANDED(收录号：WOS:001282088700016)、北大核心2023、CSTPCD、、Scopus、CSCD2023_2024、WOS、北大核心、CSCD

基金：Project supported by the National Natural Science Foundation of China (Nos. 21676166, 21302130).

语种：中文

中文关键词：铁催化;羟甲基化;可见光催化;氮杂环

外文关键词：iron catalysis;hydroxymethylation;visible-light catalysis;N-heterocycle

中文摘要：以甲醇为羟甲基化试剂,发展了一种铁催化可见光诱导氮杂环羟甲基化新方法.以FeCl_(3)为催化剂,2-甲基异烟酸为配体,对甲苯磺酸为酸,空气为氧化剂,甲醇和水为溶剂,在可见光(427 nm)诱导下实现了多种取代喹啉、异喹啉、吡啶、苯并噻唑和伏立康唑的羟甲基化,展现了该方法优秀的底物普适性.该方法具有反应条件绿色、反应原子经济性好及操作简单等优点,在药物分子或生物活性分子后续结构修饰中具有潜在的应用价值.

外文摘要：A new strategy for iron-catalyzed visible-light induced hydroxymethylation of N-heterocycles with methanol under mild conditions was developed.By employing FeCl_(3) as the catalyst,2-methylisonicotinic acid as the ligand,TsOH as the acid,air as the oxidant,and aqueous MeOH as the solvent,varieties of substituted quinolines,isoquinolines,pyridines,benzothia-zole and voriconazole were hydroxymethylated smoothly in good to excellent yields,exhibiting good substrate scope.This strategy features green reaction conditions,excellent atom-economy and simple operations.It has potential applicable value in late-stage structure modification of drug molecule.