文献类型：期刊文献

英文题名：PDGFR-beta(+) fibroblasts deteriorate survival in human solid tumors: a meta-analysis

作者：Hu, Guoming[1];Huang, Liming[1];Zhong, Kefang[1];Meng, Liwei[1];Xu, Feng[1];Wang, Shimin[2];Zhang, Tao[3]

机构：[1]Zhejiang Univ, Shaoxing Peoples Hosp, Shaoxing Hosp, Dept Gen Surg Breast & Thyroid Surg,Sch Med, Shaoxing 312000, Zhejiang, Peoples R China;[2]Zhejiang Univ, Shaoxing Peoples Hosp, Dept Nephrol, Sch Med,Shaoxing Hosp, Shaoxing 312000, Zhejiang, Peoples R China;[3]Shaoxing Univ, Dept Gen Surg 3, Affiliated Hosp, Shaoxing 312000, Zhejiang, Peoples R China

年份：2021

卷号：13

期号：10

起止页码：13693

外文期刊名：AGING-US

收录：SCI-EXPANDED(收录号：WOS:000656864700024)、、WOS

语种：英文

外文关键词：tumor-infiltrating PDGFR-beta(+) fibroblasts; worse prognosis; solid tumor; meta-analysis

外文摘要：Fibroblasts are a highly heterogeneous population in tumor microenvironment. PDGFR-beta(+) fibroblasts, a subpopulation of activated fibroblasts, have proven to correlate with cancer progression through multiple of mechanisms including inducing angiogenesis and immune evasion. However, the prognostic role of these cells in solid tumors is still not conclusive. Herein, we carried out a meta-analysis including 24 published studies with 6752 patients searched from PubMed, Embase and EBSCO to better comprehend the value of such subpopulation in prognosis prediction for solid tumors. We noted that elevated density of intratumoral PDGFR-beta(+) fibroblasts was remarkably associated with worse overall survival (OS) and disease-free survival (DFS) of patients. In subgroup analyses, the data showed that PDGFR-beta(+) fibroblast infiltration considerably decreased OS in non-small cell lung cancer (NSCLC), breast and pancreatic cancer, and reduced DFS in breast cancer. In addition, increased number of PDGFR-beta(+) fibroblasts appreciably correlated with advanced TNM stage of patients. In conclusion, PDGFR-beta(+) fibroblast infiltration deteriorates survival in human solid tumors especially in NSCLC, breast and pancreatic cancer.