文献类型：期刊文献

中文题名：慢性牙周炎患者龈沟液OPG和RANKL的变化及意义

英文题名：Change and significance of the receptor activator for NF-κB ligand and osteoprotegerin in gingival crevicular fluid in patients with chronic periodontitis

作者：柳惠荣[1];张子彦[1];郭丽香[2]

机构：[1]浙江绍兴文理学院医学院附属医院口腔科,312000;[2]太原市中心医院集团第四医院口腔科

年份：2008

卷号：24

期号：1

起止页码：129

中文期刊名：实用口腔医学杂志

外文期刊名：Journal of Practical Stomatology

收录：CSTPCD、、北大核心2004、CSCD_E2011_2012、北大核心、CSCD

语种：中文

中文关键词：牙周炎;龈沟液;核因子-kB受体活化子配体;骨保护素

外文关键词：Periodontitis ; Gingival crevicularfluid; Receptor activator for NF-kB ligand; Osteoprotegerin

中文摘要：目的:探讨慢性牙周炎患者龈沟液中核因子-κB受体活化子配体(receptor activator for NF-κBligand,RANKL)和骨保护素(osteoprotegerin,OPG)的变化及意义。方法:采用滤纸条法收集23例正常对照者和34例慢性牙周炎患者龈沟液(gingival crevicular fluid,GCF)标本,ELISA法测定上清液RANKL和OPG含量,利用Optimas5.0图像分析软件对检测牙的根尖片进行灰度分析。结果:对照组和慢性牙周炎组临床指标(PD、AL、PLI和SBI)之间存在显著性统计学差异(P<0.01)。2组GCF中RANKL、OPG和RANKL/OPG比值之间存在显著性统计学差异(P<0.01)。慢性牙周炎组GCF中OPG浓度与PD和AL之间存在负相关关系(分别为P<0.01和P<0.05),RANKL浓度及RANKL/OPG比值与根尖片灰度值之间存在负相关关系(P<0.05),GCF中RANKL和OPG浓度及RANKL/OPG比值与PLI和SBI之间无相关关系(P>0.05)。结论:RANKL和OPG在慢性牙周炎患者的牙槽骨组织破坏过程中发挥作用。

外文摘要：Objective： To investigate the changes and significance of the receptor activator for NF-kB ligand （RANKL） and osteoprotegerin（OPG） in gingival crevicular fluid（GCF） in patients with chronic periodontitis. Methods： Following careful sampling of CGF with standard filter strips in the 23 normal subjects and 34 patients with chronic periodontitis, the levels of RANKL and OPG were determined by enzyme linked immunosorbent assay （ ELISA ）, and the gray scale in the periapical film was analyzed by Optimas 5.0 software. Results：There was significant difference of clinical index of periodontitis, and levels of RANKL, OPG and the ratio of RANKL/OPG in GCF between two groups（ P 〈 0.01 ）. There was a negative correlation between level of OPG and probing depth（PD） （ P 〈 0.01 ） or attachment loss（AL） （P 〈 0.05 ）. There was a negative correlation between the level of RANKL, ratio of RANKL/OPG and the gray scale in the periapical film （ P 〈 0.05 ）. There was no significant correlation between the levels of RANKL,OPG and the ratio of RANKL/OPG in GCF and plaque index （PLI） value and sulcus bleeding index （SBI） value. Conclusion： RANKL and OPG in GCF play an important role in the osteoclastic bone destruction in chronic periodontitis.