文献类型：期刊文献

中文题名：姜黄素抑制NF-κB信号通路对脊髓损伤修复作用的研究进展

英文题名：Effect of curcumin on spinal cord injury repair via inhibiting NF-κκB signalling pathway:research progress

作者：高梦丹[1];林敬铨[1];童亮[1];张金一[1];韩娜[1];刘学红[1]

机构：[1]绍兴文理学院医学院

年份：2016

卷号：30

期号：3

起止页码：272

中文期刊名：中国药理学与毒理学杂志

外文期刊名：Chinese Journal of Pharmacology and Toxicology

收录：CSTPCD、、北大核心2014、CSCD2015_2016、Scopus、北大核心、CSCD

基金：浙江省自然科学基金(LY15H170001);绍兴市公益性技术应用研究计划资助项目(2013D10035)~~

语种：中文

中文关键词：姜黄素;NF-κB信号通路;脊髓损伤

外文关键词：curcumin; NF-κB signalling pathway; spinal cord injury

中文摘要：炎症反应是脊髓损伤(SCI)发病机制中最重要的环节,是形成脊髓继发性损伤的基础。SCI后,NF-κB信号通路过度活化,大量具有生物学活性的NF-κB迅速入核,调控靶基因引起严重的炎症反应,进一步加重组织损伤。抑制NF-κB信号通路、有效控制炎症反应是促进SCI修复的有效途径。目前发现,姜黄素能够多靶点地抑制NF-κB信号通路,阻断NF-κB过度活化和减少炎症因子的表达,在SCI修复中具有重要作用。本文就NF-κB信号通路、NF-κB信号通路在SCI中的作用机制以及姜黄素抑制NF-κB信号通路在SCI中的作用等进行综述。

外文摘要：Inflammation response is the most crucial link in the pathogeneses of spinal cord injury（SCI）,and is the basis of secondary damage. NF-κB Signalling pathway is activated excessively after SCI,so that numerous NF-κB possessing biological activities is quickly translocated into the nuclear and regulates the target genes,resulting in heightened inflammation and further tissue damage.Suppressing NF-κB signalling pathway and controlling inflammation response effectively are effective approaches to promoting SCI repair. It is found that curcumin has multiple target molecules to suppress NF-κB signalling pathway,block the excessive activation of NF-κB and reduce the expression of proinflammation cytokines,which plays an important role in SCI repair. This article discusses NF-κB signalling pathway,the contribution of NF- κB signalling pathway to SCI and the role of curcumins inhibition of NF-κB signalling pathway in SCI.