文献类型：期刊文献

英文题名：A metal-free synthesis of phosphoramidates via I--catalyzed oxidative coupling of anilines/amines with H-phosphonates

作者：Xie, Mengyu[1];Xu, Huiting[1];Zhu, Linjiao[3];Cai, Tao[1,2];Shen, Runpu[1,2]

机构：[1]Shaoxing Univ, Coll Chem & Chem Engn, Shaoxing 312000, Peoples R China;[2]Shaoxing Univ, Zhejiang Engn Res Ctr Fat Soluble Vitamin, Shaoxing 312000, Peoples R China;[3]Shaoxing Inst Food & Drug Control, Shaoxing 312000, Peoples R China

年份：2025

外文期刊名：MOLECULAR DIVERSITY

收录：SCI-EXPANDED(收录号：WOS:001555495100001)、、Scopus(收录号：2-s2.0-105013824125)、WOS

基金：Shen gratefully thanks the financial support from the Natural Science Foundation of China (Grant No. 22278270), and Cai gratefully thanks the Shaoxing Basic Public Welfare Project (No. 2023A11003), as well as the Research Project of Shaoxing University (No. 2023LG003).

语种：英文

外文关键词：H-phosphonate; Aniline; phosphoramidate; Oxidative coupling reaction

外文摘要：An efficient and environmentally benign protocol for synthesizing valuable and structurally diverse phosphoramidates via the sodium iodide (NaI)-catalyzed oxidative cross-coupling of various H-phosphonates with both aromatic and aliphatic amines. This new method utilizes H2O2 (30% aq.) as a green oxidant, ethyl acetate (EA) as a renewable, low-toxic solvent, and inexpensive, readily available NaI (10 mol%) as the sole catalyst, circumventing the need for toxic reagents, transition metal catalysts, and special equipment. It exhibits excellent compatibility with a wide range of aromatic and aliphatic amines, as well as several amino-containing pharmaceuticals, including Vortioxetine, Fluoxetine, Ceritinib, Linagliptin, and Crizotinib.