文献类型：期刊文献

英文题名：H2O2-mediated room temperature synthesis of 2-arylacetophenones from arylhydrazines and vinyl azides in water

作者：Luo, Mengqiang[1,2];Zhang, Yaohong[1];Fang, Ping[1];Li, Yan[1];Qi, Chenze[1];Li, Yong[1];Shen, Runpu[2];Cheng, Kai[1];Wang, Hai[1]

机构：[1]Shaoxing Univ, Sch Chem & Chem Engn, Sch Life Sci, Zhejiang Key Lab Alternat Technol Fine Chem Proc, Shaoxing 312000, Zhejiang, Peoples R China;[2]Shaoxing Univ, Zhejiang Engn Res Ctr Fat Soluble Vitamin, Sch Chem & Chem Engn, Shaoxing 312000, Zhejiang, Peoples R China

年份：2022

卷号：20

期号：3

起止页码：630

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:000732971000001)、、WOS、CCR-EXPANDED(收录号：WOS:000732971000001)

基金：Y This work was financially supported by the Natural Science Foundation of Zhejiang Province (No. LQ16H090004) and the National Natural Science Foundation of China (No. 12075154, 31800292 and 21801167).

语种：英文

外文关键词：Catalysts - Toxic materials

外文摘要：An environmentally benign, cost-efficient and practical methodology for the room temperature synthesis of 2-arylacetophenones in water has been discovered. The facile and efficient transformation involves the oxidative radical addition of arylhydrazines with alpha-aryl vinyl azides in the presence of H2O2 (as a radical initiator) and PEG-800 (as a phase-transfer catalyst). From the viewpoint of green chemistry and organic synthesis, the present protocol is of great significance because of using cheap, non-toxic and readily available starting materials and reagents as well as amenability to gram-scale synthesis, which provides an attractive strategy to access 2-arylacetophenones.