文献类型：期刊文献

英文题名：Polydopamine Nanoparticles-coated Curcumin Upregulates the Expression of Nrf2 Through the Keap1/ARE Signaling Pathway to Improve Liver Injury in Mice with Liver Cancer

作者：Zhou, Qingqing[1];Zhang, Zhiyuan[2]

机构：[1]Wenzhou Med Univ, Pingyang Hosp, Dept Infect Dis, Wenzhou, Zhejiang, Peoples R China;[2]Shaoxing Univ, Affiliated Xinchang Hosp, Dept Infect Dis, Shaoxing, Zhejiang, Peoples R China

年份：2025

外文期刊名：PHARMACOGNOSY MAGAZINE

收录：SCI-EXPANDED(收录号：WOS:001424974800001)、、WOS

基金：The authors gratefully acknowledge the Xinchang County People's Hospital laboratory for providing the necessary equipment for this study.

语种：英文

外文关键词：Polydopamine nanoparticles; curcumin; Keap1/ARE; Nrf2; liver cancer; liver injury

外文摘要：Background Liver cancer is a complex disease, and the upregulation of Nrf2, a key molecule in the Keap1/ARE signaling pathway, is expected to become a new method for liver cancer and prevention. Curcumin is a natural anti-oxidant, and polydopamine nanoparticles, as a new type of nano-drug carrier, have excellent biocompatibility and drug-loading performance and can improve the targeting and efficacy of drugs.Purpose: This study aims to explore the effect of polydopamine nanoparticle-encapsulated curcumin on upregulating the expression of Nrf2 through the Keap1/ARE signaling pathway, thereby improving liver damage in mice with liver cancer and providing new strategies and basis for the treatment and prevention of liver cancer.Methods After the H22 cell culture and liver cancer mouse model were established, they were divided into groups for the study of the mechanism of action of the prepared polydopamine nanoparticles-coated curcumin (CUR-PDA NPs), and the effect of CUR-PDA NPs expression on inhibition of cell proliferation and migration, promotion of apoptosis, and delaying liver cancer progression was studied through animal experiments. This process is related to the Keap1/ARE signaling pathway and Nrf2 expression. The mechanism is further verified by Add-Nrf2, Nrf2-shRNA, Keap1-shRNA, and other methods.Results CUR-PDA NPs upregulate the expression of Nrf2 through the Keap1/ARE signaling pathway to improve liver injury in mice with liver cancer. There is an interaction between the expression of CUR-PDA NPs and Keap1. Increasing the expression of Keap1 can inhibit the activation of Nrf2, thereby inhibiting the anti-oxidant and detoxification mechanisms, resulting in reduced cell survival rate, increased apoptosis rate, reduced migration, and reduced levels of IL-1 beta and TNF-alpha.Conclusion CUR-PDA NPs upregulates the expression of Nrf2 through the Keap1/ARE signaling pathway to improve liver injury in mice with liver cancer. This provides new strategies and a basis for liver cancer treatment and prevention.