文献类型：期刊文献

英文题名：3D printing processes in precise drug delivery for personalized medicine

作者：Peng, Haisheng[1];Han, Bo[2];Tong, Tianjian[3];Jin, Xin[1];Peng, Yanbo[4];Guo, Meitong[1];Li, Bian[1];Ding, Jiaxin[1];Kong, Qingfei[5];Wang, Qun[3]

机构：[1]Univ Shaoxing, Med Coll, Dept Pharmacol, Shaoxing, Peoples R China;[2]Harbin Med Univ, Dept Pharm, Daqing Branch, Daqing, Peoples R China;[3]Iowa State Univ, Dept Chem & Biol Engn, Ames, IA 50011 USA;[4]China Pharmaceut Univ, Dept Pharmaceut Engn, 639 Longmian Rd, Nanjing 211198, Peoples R China;[5]Harbin Med Univ, Dept Neurobiol, Heilongjiang Prov Key Lab Neurobiol, Harbin, Heilongjiang, Peoples R China

年份：2024

卷号：16

期号：3

外文期刊名：BIOFABRICATION

收录：SCI-EXPANDED(收录号：WOS:001204285900001)、、EI(收录号：20241715949517)、Scopus(收录号：2-s2.0-85190731877)、WOS

基金：Dr Peng is grateful for the support from Joint fund of Shaoxing University and Shaoxing Institute of Zhejiang University (2023LHLG007), the National Natural Science Foundation of China (No. 81671814) and the Heilongjiang Provincial Natural Science Foundation (No. ZD2016013). Dr Wang thanks to the support from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) Trailblazer Award (1R21EB032991-01) and the Shanti V Sitaraman, MD, PhD Inflammatory Bowel Diseases Young Investigator Award (No. 439516).

语种：英文

外文关键词：personalized medicine; 3D printing; dosage form; precise drug delivery

外文摘要：With the advent of personalized medicine, the drug delivery system will be changed significantly. The development of personalized medicine needs the support of many technologies, among which three-dimensional printing (3DP) technology is a novel formulation-preparing process that creates 3D objects by depositing printing materials layer-by-layer based on the computer-aided design method. Compared with traditional pharmaceutical processes, 3DP produces complex drug combinations, personalized dosage, and flexible shape and structure of dosage forms (DFs) on demand. In the future, personalized 3DP drugs may supplement and even replace their traditional counterpart. We systematically introduce the applications of 3DP technologies in the pharmaceutical industry and summarize the virtues and shortcomings of each technique. The release behaviors and control mechanisms of the pharmaceutical DFs with desired structures are also analyzed. Finally, the benefits, challenges, and prospects of 3DP technology to the pharmaceutical industry are discussed.