文献类型：期刊文献

英文题名：Hyaluronic acid-poly(glyceryl)10-stearate nanoemulsion for co-delivery of fish oil and resveratrol: Enhancing bioaccessibility and antioxidant potency

作者：Ao, Sha[1,2];Luo, Xiang[1,2];Huang, Mengyu[2];Wu, Hongze[1,2];Chen, Yuanyuan[1];Chen, Haonan[2];Li, Jiafei[2];Zhou, Yanyan[1];Yin, Xuguang[1];Cai, Tao[2];Yang, Qun[3];Deng, Liping[2];Zhu, Kewu[1]

机构：[1]Shaoxing Univ, Ctr Drug Delivery Syst Res, Sch Med, 900 Chengnan Ave, Shaoxing 312000, Zhejiang, Peoples R China;[2]Shaoxing Univ, Coll Chem & Chem Engn, Zhejiang Engn Res Ctr Fat soluble Vitamin, 900 Chengnan Ave, Shaoxing 312000, Zhejiang, Peoples R China;[3]Shaoxing Univ, Yuanpei Coll, Sch Med & Hlth, 2799 Qunxian Middle Rd, Shaoxing 312000, Zhejiang, Peoples R China

年份：2024

卷号：273

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：SCI-EXPANDED(收录号：WOS:001258753400001)、、EI(收录号：20242516263943)、Scopus(收录号：2-s2.0-85195881995)、WOS

基金：This study was financially supported by the General Scientific Research Projects of Zhejiang Provincial Department of Education (Grant No. Y202351486) , the Joint Research Program of Shaoxing University and Shaoxing Institute, Zhejiang University (Grant No. 2023LHLG004) , as well as the Applied Technology Research and Development Plan Project of Heilongjiang Province (Grant No. GA19C105) .

语种：英文

外文关键词：Hyaluronic acid; Poly(glyceryl)10-stearate; Nanoemulsions; Fish oil; Resveratrol; Stability

外文摘要：Hyaluronic acid (HA), an endogenous polysaccharide comprising alternating D-glucuronic acid and N-acetylglucosamine units, is renowned for its high hydrophilicity, biocompatibility, and biodegradability. These attributes have rendered HA invaluable across medical and drug delivery fields. HA can be altered through physical, chemical, or enzymatic methods to improve the properties of the modified substances. In this work, we synthesized a derivative via the esterification of HA with poly(glyceryl)10-stearate (PG10-C18), designated as HAPG10-C18. This novel derivative was employed to fabricate a nano co-delivery system (HA-PG10-C18@Res-NE) for fish oil and resveratrol (Res), aiming to enhance their stability and bioaccessibility. An exhaustive investigation of HA-PG10-C18@Res-NE revealed that the HA-modified system displayed superior physicochemical stability, notably in withstanding oxidation and neutralizing free radicals. Moreover, in vitro simulated digestion underscored the system's enhanced bioaccessibility of Res and more efficient release of free fatty acids. These outcomes underscore the strategic advantage of HA in modifying PG10-C18 for nanoemulsion formulation. Consequently, HA-PG10-C18 stands as a promising emulsifier for encapsulating lipophilic bioactives in functional foods, nutraceuticals, and pharmaceuticals.