文献类型：期刊文献

英文题名：Meta-analysis of sleep deprivation effects on depression in rodents

作者：Hu, Baiqi[1,2,3];Liu, Chunyan[4];Lv, Tingting[2];Luo, Fangyi[2];Qian, Chao[1];Zhang, Jian[2];Ye, Mengfei[1,2];Liu, Zheng[2]

机构：[1]Shaoxing Univ, Shaoxing Peoples Hosp 7, Affiliated Mental Hlth Ctr, Dept Psychiat,Med Coll, Shaoxing 312000, Zhejiang, Peoples R China;[2]Shaoxing Univ, Sci Res Ctr, Dept Behav Neurosci, Med Sch, Shaoxing 312000, Zhejiang, Peoples R China;[3]China Med Univ, Shaoxing Hosp, Dept Neurol, Shaoxing, Zhejiang, Peoples R China;[4]Shaoxing Peoples Hosp, Dept Orthoped, Shaoxing, Zhejiang, Peoples R China

年份：2022

卷号：1782

外文期刊名：BRAIN RESEARCH

收录：SCI-EXPANDED(收录号：WOS:000792764600005)、、Scopus(收录号：2-s2.0-85126149425)、WOS

基金：Acknowledgments This work was funded by the Public Welfare Technology Applied Research Projects in Zhejiang Province (no. 2016C33191) and the Zhejiang Medical Health Science and Technology Project (no. 2019KY724, 2020KY332) .

语种：英文

外文关键词：Sleep deprivation; Depression; Tail suspension test; Forced swimming test; Sucrose preference test; Meta-analysis; Rodents

外文摘要：Objective: To our knowledge, the relationship of sleep deprivation (SD) and depression on the rodents remains unclear. In this article, we performed a meta-analysis to provide a comprehensive evaluation of the experimental effects of SD on rodents and explore the heterogeneous factors that may be associated with outcomes.& nbsp;Methods: PubMed, Embase, the Cochrane Library, and Web of Science were searched for articles before January 5th, 2022. The strains of rodents, SD method, and depression measurement tools were recorded. Standardized mean differences based on Hedge's g were calculated as measures of the effect size.& nbsp;Results: In total, 19 studies involving 51 trials were included. The overall data suggested that SD had a large effect on exacerbating depression-like behaviors, but there was high heterogeneity [-1.09 (-1.57,-0.62); I-2 = 90.3%; P < 0.05]. Subgroup analysis showed that tail suspension test better reflected the effect of SD in exacerbating depression-like behavior [-3.677 (-4.758,-2.597); I-2 = 56.7%; P = 0.001] than forced swimming test [-0.821 (-1.439,-0.203); I-2 = 91%; P = 0.009] and sucrose preference test [-1.033 (-1.709,-0.358); I-2 = 81.6%; P 1/4 0.003].& nbsp;Conclusion: This study found that SD worsened depression-like behaviors by tail suspension test. Our results also indicated that the effects of SD on depression in rodents were related to different assessment methods, strains, SD methods and SD types.