文献类型：期刊文献

英文题名：Chemistry, bioactivity, biosynthesis, and total synthesis of stemmadenine alkaloids

作者：Fan, Minghui[1];Zou, Liangbang[1];Tian, Kaidi[1];Chen, Guoqing[1];Cheng, Kai[1];Li, Yong[1]

机构：[1]Shaoxing Univ, Zhejiang Key Lab Alternat Technol Fine Chem Proc, Shaoxing 312000, Peoples R China

年份：0

外文期刊名：NATURAL PRODUCT REPORTS

收录：SCI-EXPANDED(收录号：WOS:000921908900001)、、Scopus(收录号：2-s2.0-85147771813)、WOS

基金：Sincere thanks are given to Prof. Zhaoyong Lu (Nankai University), Prof. Shugao Zhu (Nanchang University), Ms Pengxi Chen for helpful discussions. Financial support was provided by the National Natural Science Foundation of China (Grant No. 21801167) and the Zhejiang Provincial Natural Science Foundation of China (Grant No. LQ17B020002).

语种：英文

外文摘要：Covering: up to July 2022 Stemmadenine alkaloids are a restrictive sub-group of monoterpene indole alkaloids, represented by two congeners: stemmadenine and vallesamine. Their skeleton is defined by the cleavage of the C-3-C-7 bond of the Strychnos group's pentacyclic scaffold in monoterpene indole alkaloids. The parent alkaloid stemmadenine acts as a key intermediate in the biosynthesis of several major monoterpene indole alkaloid families, including regular Strychnos alkaloids, Aspidosperma alkaloids, and Iboga alkaloids. In this review, a complete coverage of the stemmadenine alkaloids, from the early reports till the present day at 2022, are presented, and their diverse biological activities are briefly described. Moreover, the biosynthetic proposal for stemmadenine and the proposed biogenetic conversion of stemmadenine-type alkaloids into vallesamine-type congeners are discussed in detail. Moreover, the successful synthetic strategies to access the strained stemmadenine scaffolds are fully reviewed.