文献类型：期刊文献

英文题名：Progress in long non-coding RNAs as prognostic factors of papillary thyroid carcinoma

作者：Zhu, Hao-nan[1];Song, Dong-liang[1];Zhang, Si-nan[1];Zheng, Zhao-jie[1];Chen, Xing-yu[1];Jin, Xin[1]

机构：[1]Shaoxing Univ, Med Coll, Dept Clin Med, Shaoxing 312000, Zhejiang, Peoples R China

年份：2024

卷号：256

外文期刊名：PATHOLOGY RESEARCH AND PRACTICE

收录：SCI-EXPANDED(收录号：WOS:001207492800001)、、Scopus(收录号：2-s2.0-85187324247)、WOS

基金：This work was financially supported by the opening foundation of the State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine (SKLID2023KF03) , the Zhejiang Basic Public Welfare Project (LGF18H160014) , and the College Student's Science and Technology Innovation Activity Plan of Zhejiang Province (Xinmiao Talent Project) (2023R465020) .

语种：英文

外文关键词：Diagnosis; LncRNAs; Mechanisms; Papillary thyroid carcinoma; Prognosis

外文摘要：Papillary thyroid carcinoma (PTC) is generally recognized as a slow-growing tumor. However, a small subset of patients may still experience relapse or metastasis shortly after therapy, leading to a poor prognosis and raising concerns about excessive medical treatment. One major challenge lies in the inadequacy of effective biomarkers for accurate risk stratification. Long non-coding RNAs (lncRNAs), which are closely related to malignant characteristics and poor prognosis, play a significant role in the genesis and development of PTC through various pathways. The objective of this review is to provide a comprehensive summary of the biological functions of lncRNAs in PTC, identify prognosis-relevant lncRNAs, and explore their potential mechanisms in drug resistance to BRAF kinase inhibitors, tumor dedifferentiation, and lymph node metastasis. By doing so, this review aims to offer valuable references for both basic research and the prediction of PTC prognosis.