文献类型：期刊文献

英文题名：Maresin1 can be a potential therapeutic target for nerve injury

作者：Wang, Xichen[1];Botchway, Benson O. A.[2,3];Zhang, Yong[1];Huang, Min[1];Liu, Xuehong[1,4]

机构：[1]Shaoxing Univ, Sch Med, Dept Histol & Embryol, Shaoxing, Zhejiang, Peoples R China;[2]Zhejiang Univ, Sch Med, Inst Neurosci, Hangzhou, Peoples R China;[3]Bupa Cromwell Hosp, London, England;[4]Shaoxing Univ, Med Coll, Dept Histol & Embryol, Shaoxing 312000, Zhejiang, Peoples R China

年份：2023

卷号：161

外文期刊名：BIOMEDICINE & PHARMACOTHERAPY

收录：SCI-EXPANDED(收录号：WOS:000949965300001)、、Scopus(收录号：2-s2.0-85149297611)、WOS

基金：The Natural Science Foundation of Zhejiang Province supported this work (no. LY19H170001) .

语种：英文

外文关键词：Maresin1; Inflammation; Nerve injury; Therapeutic target; Macrophages; Neuronal protection

外文摘要：Nerve injury significantly affects human motor and sensory function due to destruction of the integrity of nerve structure. In the wake of nerve injury, glial cells are activated, and synaptic integrity is destroyed, causing inflammation and pain hypersensitivity. Maresin1, an omega-3 fatty acid, is a derivative of docosahexaenoic acid. It has showed beneficial effects in several animal models of central and peripheral nerve injuries. In this review, we summarize the anti-inflammatory, neuroprotective and pain hypersensitivity effects of maresin1 in nerve injury and provide a theoretical basis for the clinical treatment of nerve injury using maresin1.