文献类型：期刊文献

英文题名：Synthesis and In Vitro Characterization of Fe3+-Doped Layered Double Hydroxide Nanorings as a Potential Imageable Drug Delivery System

作者：Wang, Lijun[1];Wang, Yusen[1];Wang, Xiaoxia[1]

机构：[1]Shaoxing Univ, Sch Chem & Chem Engn, Shaoxing 312000, Peoples R China

年份：2017

卷号：10

期号：10

外文期刊名：MATERIALS

收录：SCI-EXPANDED(收录号：WOS:000414639000035)、、WOS

基金：We greatly acknowledge the financial support from the National Natural Science Foundation of China (Grant No. 51402195). We thank Shengjian Zhang from the department of radiology, Shanghai Cancer Hospital, for the MRI tests.

语种：英文

外文关键词：nanostructure; layered double hydroxides; MRI; drug carrier

外文摘要：Highly dispersed Fe3+-doped layered double hydroxide (LDH-Fe) nanorings were obtained by a simple coprecipitation-acid etching approach. The morphology, structure, magnetic resonance imaging (MRI) performance in vitro, drug loading and releasing, Fe3+ leakage, and cytotoxicity of the as-prepared LDH-Fe nanorings were characterized. The LDH-Fe nanorings showed good water dispersity and a well-crystallized structure. The DLS average size of nanoparticles was measured to be 94.5 nm. Moreover, the MRI tests showed a favourable T-1-weighted MRI performance of the LDH-Fe nanoring with r(1) values of 0.54 and 1.68, and low r(2)/r(1) ratios of 10.1 and 6.3, pre- and after calcination, respectively. The nanoparticles also showed high model drug (ibuprofen) loading capacities, low Fe3+ leakage, and negligible cytotoxicity. All these results demonstrate the potential of LDH-Fe nanorings as an imageable drug delivery system.