文献类型：期刊文献

英文题名：Yellow Wine Polyphenolic Compound Protects Against Doxorubicin-Induced Cardiotoxicity by Modulating the Composition and Metabolic Function of the Gut Microbiota

作者：Lin, Hui[2];Meng, Liping[2];Sun, Zhenzhu[3];Sun, Shiming[4];Huang, Xingxiao[5];Lin, Na[6];Zhang, Jie[2];Lu, Wenqiang[5];Yang, Qi[6];Chi, Jufang[2];Guo, Hangyuan[1]

机构：[1]Shaoxing Univ, Coll Med, 508 Huancheng W Rd, Shaoxing 312000, Zhejiang, Peoples R China;[2]Zhejiang Univ, Shaoxing Peoples Hosp, Shaoxing Hosp, Dept Cardiol,Sch Med, Hangzhou, Zhejiang, Peoples R China;[3]Taizhou Hosp Zhejiang Provence, Dept Cardiol, Taizhou, Peoples R China;[4]Wenzhou Med Univ, Clin Med Coll 1, Wenzhou, Zhejiang, Peoples R China;[5]Zhejiang Univ, Sch Med, Hangzhou, Peoples R China;[6]Zhejiang Chinese Med Univ, Hangzhou, Peoples R China

年份：2021

卷号：14

期号：10

起止页码：1136

外文期刊名：CIRCULATION-HEART FAILURE

收录：SCI-EXPANDED(收录号：WOS:000708619000008)、、Scopus(收录号：2-s2.0-85119391694)、WOS

基金：This work was supported by grants from the National Natural Science Foundation of China (grants 81873120 and 82000252), Zhejiang Provincial Natural Science Foundation of China (grants LGF19H020006, LGF19H020002, LBY20H020001, and LGF21H020001), Science and Technology Project of Shaoxing (grants 2019B24004), and the Key Laboratory of Cardio-Cerebral Vascular Disease Rehabilitation Technology Innovation and Application of Shaoxing City (grant 2020ZDSYS02).

语种：英文

外文关键词：cardiotoxicity; doxorubicin; gastrointestinal microbiome; metabolomics; polyphenols

外文摘要：Background: Dietary polyphenols help to prevent cardiovascular diseases, and interactions between polyphenols and gut microbiota are known to exist. In this study, we speculated that gut microbiota-mediated metabolite regulation might contribute to the anticardiotoxic effects of yellow wine polyphenolic compound (YWPC) in doxorubicin (DOX)-treated rats. Methods: 16S-rDNA sequencing was performed to analyze the effects of YWPC on the gut microbiota in DOX-treated rats (n=6). Antibiotics were used to investigate the contribution of the altered microbiome to the role of YWPC (n=6). Plasma metabolomics were also analyzed by untargeted gas chromatography-mass spectrometry systems. Results: YWPC ameliorated DOX-mediated cardiotoxicity, as evidenced by increased cardiac and mitochondrial function and reduced levels of inflammation and myocardial apoptosis (P<0.05 for all). The low abundance of Escherichia-Shigella, Dubosiella, and Allobaculum, along with enrichment of Muribaculaceae_unclassified, Ralstonia, and Rikenellaceae_RC9_gut_group in the gut, suggested that YWPC ameliorated DOX-induced microbial dysbiosis. YWPC also influenced the levels of metabolites altered by DOX, resulting in lower arachidonic acid and linoleic acid metabolism and higher tryptophan metabolite levels (P<0.05 for all). Correlational studies indicated that YWPC alleviated DOX-induced inflammation and mitochondrial dysfunction by modulating the gut microbial community and its associated metabolites. Antibiotic treatment exacerbated cardiotoxicity in DOX-treated rats, and its effect on the gut microbiota partly abolished the anticardiotoxic effects of YWPC, suggesting that the microbiota is required for the cardioprotective role of YWPC. Conclusions: YWPC protected against DOX-induced cardiotoxicity in a gut microbiota-dependent manner. This supports the use of dietary polyphenols as a therapeutic approach for the treatment of cardiovascular diseases via microbiota regulation.