文献类型：期刊文献

英文题名：Functional polarization of tumor-associated macrophages dictated by metabolic reprogramming

作者：Zeng, Wentao[1];Li, Fei[1];Jin, Shikai[1];Ho, Ping-Chih[2,3];Liu, Pu-Ste[4];Xie, Xin[1]

机构：[1]Shaoxing Univ, Sch Life Sci, Shaoxing 312000, Zhejiang, Peoples R China;[2]Univ Lausanne, Fac Biol & Med, Dept Fundamental Oncol, Lausanne, Switzerland;[3]Ludwig Lausanne Branch, Lausanne, Switzerland;[4]Natl Hlth Res Inst, Inst Cellular & Syst Med, Miaoli, Taiwan

年份：2023

卷号：42

期号：1

外文期刊名：JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

收录：SCI-EXPANDED(收录号：WOS:001069339000001)、、Scopus(收录号：2-s2.0-85171864722)、WOS

基金：Not applicable

语种：英文

外文关键词：TAMs; TME; Metabolic reprogramming; Polarization; Signaling pathways

外文摘要：Macrophages are highly plastic in different tissues and can differentiate into functional subpopulations under different stimuli. Tumor-associated macrophages (TAMs) are one of the most important innate immune cells implicated in the establishment of an immunosuppressive tumor microenvironment (TME). Recent evidence pinpoints the critical role of metabolic reprogramming in dictating pro-tumorigenic functions of TAMs. Both tumor cells and macrophages undergo metabolic reprogramming to meet energy demands in the TME. Understanding the metabolic rewiring in TAMs can shed light on immune escape mechanisms and provide insights into repolarizing TAMs towards anti-tumorigenic function. Here, we discuss how metabolism impinges on the functional divergence of macrophages and its relevance to macrophage polarization in the TME.