文献类型：期刊文献

英文题名：Polysaccharide immunization and colorectal cancer: A systematic review and network meta-analysis

作者：Chen, Yuefeng[1];Pan, Xinnan[2];Tian, Baoming[3,4,5];Hu, Yajun[1]

机构：[1]Shaoxing Univ, Dept Med Coll, Shaoxing, Peoples R China;[2]Wenzhou Med Univ, Dept Med Coll, Wenzhou, Peoples R China;[3]Zhejiang Univ Technol, Coll Food Sci & Technol, Hangzhou, Peoples R China;[4]Modern TCM & Nat Med Co Ltd, Zhejiang Inst, Hangzhou, Peoples R China;[5]Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou, Peoples R China

年份：2022

卷号：9

外文期刊名：FRONTIERS IN NUTRITION

收录：SCI-EXPANDED(收录号：WOS:000837079900001)、、Scopus(收录号：2-s2.0-85135462677)、WOS

基金：This work was sponsored by the School-Enterprise Cooperation Project Fund of Zhejiang University of Technology (KYY-HX-20211132).

语种：英文

外文关键词：colorectal cancer; CD24; prognosis; polysaccharides; immune

外文摘要：Polysaccharides have a variety of biological activities, and in the anti-tumor field, they produce tumor suppressive effects by regulating the polarization of tumor-associated macrophages (TAMs). In immunotherapy, it has significant activities in modulating cytokines and antibody production. We reviewed them and selected CD24, an immune target, for meta-analysis with colorectal cancer (CRC) to investigate the correlation between CD24 expression and CRC. Correlation of CD24 positive expression with clinical-pathological features: age, sex, Duke's stage, diameter, depth of invasion, degree of differentiation, and lymph node metastasis. It showed that: CD24 expression in CRC was significantly correlated with advanced nuclear grade of CRC, lymph node metastasis, Duke's stage of CRC and age of CRC patients, while there was no significant correlation with gender, tumor diameter and invasion depth. The aim is to clarify the specific mechanism of polysaccharide immune anti-tumor, combined with targeted site-specific anti-solid tumor.